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INTERNATIONAL ANGIOLOGY

Rivista di Angiologia


Official Journal of the International Union of Angiology, the International Union of Phlebology and the Central European Vascular Forum
Indexed/Abstracted in: BIOSIS Previews, Current Contents/Clinical Medicine, EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
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International Angiology 2017 December;36(6):574-9

DOI: 10.23736/S0392-9590.17.03849-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Correlation between biological characteristics of thrombus and short-term efficiency of thrombolytic therapy by acoustic radiation force impulse imaging technique

Xiaolei YI 1, 2, Caifang NI 1 , MingMing LI 1, Qiong WU 2, Yi LI 2

1 Department of Interventional Radiology, First Affiliated Hospital of Soochow University, Suzhou, China; 2 Department of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Institute of Ultrasound in Medicine, Shanghai, China


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BACKGROUND: The aims of this paper were to evaluate the biological characteristics of lower extremity deep venous thrombosis (DVT) by applying acoustic radiation force impulse imaging technique (ARFI), explore the correlation between the value of shear wave speed (SWV) and short-term efficacy of thrombolytic therapy as well as analyze the application value of shear wave velocity in predicting the short-term efficacy of thrombolytic therapy.
METHODS: ARFI for 120 patients with lower extremity DVT was examined and the shear wave velocity values were measured. The thrombus SWV value among the cured group, effective treatment group and ineffective group according to the different effect of thrombolytic therapy and were analyzed and then the cured and effective treatment group were classified into total effective group. The effectiveness and thrombus SWV were compared. The Receiver Operating Characteristic was constructed and the critical effective value of SWV thrombolysis were evaluated.
RESULTS: The SWV value has a certain correlation with the effect of thrombolysis. The thrombus in cured group and effective treatment group were significantly less than the ineffective group. There was no significant thrombus hardness difference between cured group and effective group. SWV value can predict the effect of thrombolytic therapy. The critical value was 1.925, which was greater than that of the patients with a poor prognosis, with a sensitivity of 65.59% and a specificity of 88.89%.
CONCLUSIONS: The SWV value has a certain correlation with the thrombolysis effect. The biological characteristics of lower extremity DVT can be evaluated by acoustic pulse radiation force imaging technology, which has high value for the clinical treatment plan and the prediction of thrombolysis effect.


KEY WORDS: Thrombosis - Thrombolytic therapy - Diagnostic imaging

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Publication History

Issue published online: November 23, 2017
Article first published online: May 24, 2017
Manuscript accepted: May 22, 2017
Manuscript received: April 25, 2017

Per citare questo articolo

Yi X, Ni C, Li M, Wu Q, Li Y. Correlation between biological characteristics of thrombus and short-term efficiency of thrombolytic therapy by acoustic radiation force impulse imaging technique. Int Angiol 2017;36:574-9. DOI: 10.23736/S0392-9590.17.03849-4

Corresponding author e-mail

usdoc2015@yeah.net