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International Angiology 2017 December;36(6):545-52

DOI: 10.23736/S0392-9590.17.03850-0


lingua: Inglese

Evaluation of cerebral perfusion by contrast-enhanced ultrasound at low mechanical index in cerebral ischemia rat model

Xiaolei WANG 1, Bo LIU 2, Jiongou LIU 1, Aitong SUN 3, Yan CUI 1, Rui XIAO 4, Chunyang LI 5

1 Department of Ultrasound, the Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China; 2 Department of Ultrasound, the 253th Hospital of P.L.A., Huhhot, China; 3 Department of Ultrasound, People’s Hospital of Inner Mongolia, Huhhot, China; 4 Key Laboratory Of Molecular Pathology, Inner Mongolia Medical University, Huhhot, China; 5 Department of Neurology, the Affiliated Hospital of Inner Mongolia Medical University, Huhhot, China


BACKGROUND: No data is available for brain low mechanical index (low-MI) contrast-enhanced ultrasound (CEUS). This study aimed to assess low-MI CEUS for cerebral ischemia in rats.
METHODS: Twenty adult Wistar rats were divided to the brain ischemia (N.=12) and sham (N.=8) groups. A Logiq E9 (GE; ML6-15 probe) was used. Bolus injection of SonoVue (Bracco) at 3.6 mL/kg was performed. Cerebral perfusion was evaluated using time to peak (TTP) and area under the curve (AUC) of time-intensity curves (TIC).
RESULTS: There was a decrease in peak systolic BFV of anterior cerebral and middle cerebral arteries in ischemic rats and a sharp increase in peak systolic BFV of basilar artery compared with sham rats (all P<0.01). Microbubble enhancement occurred in the Willis circle, followed by diencephalon and telencephalon. The AUC and TTP of the region of interest at telencephalon were significantly different between the two groups; in addition, the differences with the diencephalon were also significant (all P<0.01). There were differences in AUC and TTP between the telencephalon and diencephalon of the same group (all P<0.05).
CONCLUSIONS: Real-time low-MI CEUS could sensitively demonstrate dynamic microbubble enhancement in brain tissues and allows semi-quantitative assessment of cerebral perfusion after ischemic brain injury using TIC.

KEY WORDS: Contrast media - Ultrasonography - Microbubbles - Perfusion - Brain ischemia

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