ORIGINAL ARTICLES   

International Angiology 2012 February;31(1):28-32

Copyright © 2012 EDIZIONI MINERVA MEDICA

lingua: Inglese

Impact of carotid artery stenting on plasma interleukin-6, tumor necrosis factor-α and C-reactive protein

Xia Z. Y. ¹, Yang H. ², Qu H. Q. ¹, Cheng W. D. ¹, Wang L. X. ³ ✉

¹ Department of Neurology, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University Liaocheng, Shandong Province 252000, PR China; ² Department of Neurology, The Third People’s Hospital of Liaocheng,Liaocheng, Shandong Province, 252000, PR China; ³ School of Biomedical Sciences,Charles Sturt University, Wagga Wagga, NSW 2678, Australia

AIM:This study aimed to investigate the impact of carotid artery stenting (CAS) on plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP).
METHODS: The levels of CRP, IL-6, and TNF-α were measured in 61 patients before CAS, 1 h, 2 weeks, 1 month, 6 months, and 12 months after the stenting.
RESULTS: The levels of CRP, IL-6 and TNF-α increased immediately after CAS (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-α in patients receiving two stents for multiple lesions or single diffusive lesions was also high than in patients receiving one stent for a single lesion (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-α in patients with restenosis (14/61, or 23%) were higher than in those without restenosis (P<0.05 or <0.01).
CONCLUSION: CAS was associated with a significant increase in plasma CRP, IL-6 and TNF-α. The levels of these inflammatory factors in patients with post-CAS restenosis were higher than in those without restenosis.