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International Angiology 2006 June;25(2):216-20

Copyright © 2006 EDIZIONI MINERVA MEDICA

lingua: Inglese

Decreased vascular reactivity to α1 adrenergic stimulation in the presence of hypothyroid state: a part of an adaptive response?

Pantos C. 1, Mourouzis C. 1, Katramadou M. 1, Saranteas T. 1, Mourouzis I. 1, Karageorgiou H. 1, Tesseromatis C. 1, Kostopanagiotou G. 1, Asimacopoulos P. 1, Cokkinos D. V. 2

1 Department of Pharmacology, University of Athens, Athens,Greece 2 1st Cardiology Department, Onassis Cardiac Surgery Center, Athens, Greece


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Aim. A hypothyroid state frequently accompanies cardiac illnesses but its physiological significance for the cardiovascular hemodynamics remains largely unknown. Therefore, the present study investigated possible physiological consequences on vascular function in an experimental model of low thyroid hormone state.
Methods. Hypothyroidism was induced in rats by the administration of 6-n-propyl-2-thiouracil in drinking water (final concentration of 0.05%) for 3 weeks, HYPO rats, and untreated rats served as controls (Control). Isolated aortic rings with or without endothelium (E+, E-) were contracted with KCl (10 to 60 mM) and phenylephrine (PE) (10-10 to 10-5 M). Maximal tension (Tmax) in g and EC50 in response to PE and KCl were measured.
Results. Tmax was significantly lower while EC50 was significantly higher in response to PE in HYPO(E+) than in Control(E+). Upon endothelium removal, Tmax was not significantly different between the groups but EC50 was still significantly higher in HYPO(E-) than in Control(E-). EC50 in response to KCl was significantly higher in HYPO with or without endothelium and no difference was found in Tmax.
Conclusion. Hypothyroid aortic rings respond less to α1 adrenergic stimulation probably due to the endothelium modulatory effect as well as to intrinsic smooth muscle defect. This seems to be of important clinical relevance.

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