ORIGINAL ARTICLES   

International Angiology 2003 December;22(4):431-7

Copyright © 2003 EDIZIONI MINERVA MEDICA

lingua: Inglese

Effect of diclofenac sodium on the healing process of end-to-end anastomosis in carotid arteries of rabbits. Histopathological and biomechanical studies

Freire Cerqueira N. ¹, Hussni C. A. ¹, Bonetti Yoshida W. ², Swain Müller S. ², Sequeira J. L. ³, Rodrigues A. C. ⁴, Mattar L. ², Crocci A. J. ⁵

¹ Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University, São Paulo, Brazil 2 Department of Surgery and Orthopedics, School of Medicine, São Paulo State University, São Paulo, Brazil 3 Department of Clinical Veterinary, School of Veterinary Medicine and Animal Science, São Paulo State University, São Paulo, Brazil 4 Department of Anatomy, Institute of Biosciences, São Paulo State University, São Paulo, Brazil 5 Department of Bioestatistics, Institute of Biosciences, São Paulo State University, São Paulo, Brazil

Aim. Diclof­e­nac sodi­um is a non-ster­oid­al anti-inflam­ma­to­ry drug com­mon­ly used to atten­u­ate pain­ful inflam­ma­to­ry reac­tions in sur­gery. How­ev­er, it may delay heal­ing in the skin and gas­troin­tes­ti­nal tract. The aim of this study was to eval­u­ate the influ­ence of Diclof­e­nac in vas­cu­lar heal­ing.
Meth­ods. Nine­ty rab­bits had their carot­id arter­ies sec­tioned and recon­struct­ed by end-to-end anas­tom­o­sis with inter­rupt­ed ­sutures. The ani­mals were ran­dom­ly allo­cat­ed into 3 ­groups of 30 each and treat­ed by intra­mus­cu­lar route with ­saline (con­trol), 5 mg/kg/day of diclof­e­nac sodi­um (DS-5), and 10 mg/kg/day of diclof­e­nac sodi­um (DS-10). Treat­ment began on the day of sur­gery and last­ed 4 days. Angio­gra­phy, bio­me­chan­i­cal prop­er­ties (fail­ure load, fail­ure elon­ga­tion, yield point, yield point elon­ga­tion, and stiff­ness were ­obtained from the load/elon­ga­tion curve), mac­ro­scop­ic and his­to­log­i­cal exam­ina­tions (hem­a­tox­y­lin-eosin, Mas­son, Cal­le­ja, Picros­sir­i­us-red), and scan­ning elec­tron micros­co­py were stud­ied in both arter­ies on the 3rd and 15th post­op­er­a­tive days.
­Results. No sig­nif­i­cant dif­fer­enc­es in bio­me­chan­i­cal prop­er­ties were ­observed ­either in the 3 ­groups or the experi­men­tal times. The carot­id ­artery heal­ing pro­cess was sim­i­lar in the 3 ­groups.
Con­clu­sion. Diclof­e­nac sodi­um did not cause alter­a­tions nor ­delayed carot­id ­artery heal­ing.