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International Angiology 2003 June;22(2):134-40


lingua: Inglese

Healing process in anastomosis of homologous venous grafts preserved in glutaraldehyde implanted aorta of rabbits

Moura R. 1, Yoshida W. B. 1, Fabris V. E. 2, Angeleli A. Y. O. 3, Naresse L. E. 1, Maffei F. H. A. 1

1 Department of Surgery and Orthopedics, School of Medicine of Paulista State University, Botucatu, São Paulo, Brazil 2 Department of Pathology, School of Medicine of Paulista State University, Botucatu, São Paulo, Brazil 3 Department of Medicine, School of Medicine of Paulista State University, Botucatu, São Paulo, Brazil


Aim. Autol­o­gous vein (AV) is some­times not suit­able or ­present for a vas­cu­lar res­to­ra­tion. Homol­o­gous vein pre­served in glu­ta­ral­de­hyde may be an alter­na­tive to AV, but lit­tle is yet known about this graft and its heal­ing pro­cess after implan­ta­tion in arter­ies. The pur­pose of this study was to com­pare the ­initial heal­ing pro­cess of glu­ta­ral­de­hyde-­tanned homol­o­gous ­venous ­grafts (group 1) with fresh autol­o­gous ­venous ­grafts (group 2), at 4 or 15 days.
Meth­ods. Forty Nor­folk rab­bits were allo­cat­ed in 2 ­groups of 20 ani­mals each. The ­grafts was inter­posed in the infra­ren­al aorta of the rab­bit. Anas­to­mot­ic ten­sile ­strength (TS), hydrox­y­pro­line (HP) deter­mi­na­tion, and his­tol­o­gy (HA) were per­formed.
­Results. TS ­increased in both ­groups, from the 4th to 15th day, (p<0.01) in both prox­i­mal (G1: from 364.5±98.3 g to 491.8±107.3 g; G2: from 366.26±85.15 g to 518.46±82.79 g) and dis­tal anas­tom­o­sis (G1: from 363.53±96.26 g to 507.32±91.01 g; G2: from 352.30±102.41 g to 528.67±48.58 g), with no dif­fer­ence ­between the ­groups. HP did not ­change (p>0.10) in this same peri­od and was sim­i­lar in both ­groups, in the prox­i­mal (G1: from 677.99±153.98 µg/100 mg to 914.92±459.83 µg/100 mg; G2: from 668.65±170.28 µg/100 mg to 669.46±319.80 ug/100 mg) as well as in the dis­tal anas­tom­o­sis (G1: from 740.07±213.53 µg/100 mg to 923.52±270.57 µg/100 mg; G2: from 737.66±266.76 µg/100 mg to 707.68±171.25 µg/100 mg). ­Initial inflam­ma­to­ry and rep­ar­a­tive fea­tures of the anas­tom­o­sis were sim­i­lar in both ­groups.
Con­clu­sion. We can con­clude that the heal­ing pro­cess of the glu­ta­ral­de­hyde-­tanned homol­o­gous vein graft was sim­i­lar to that of the fresh autol­o­gous ­venous graft.

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