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International Angiology 2001 June;20(2):148-51

Copyright © 2002 EDIZIONI MINERVA MEDICA

lingua: Inglese

The PIA1/A2 polymorphism of platelet glycoprotein IIIa is not associated with deep venous thrombosis

Renner W., Winkler M., Hoffmann C., Köppel H., Brodmann M., Pilger E.

From the Division of Angiology, Department of Medicine, University Hospital, Graz, Austria


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Back­ground. Plate­let gly­co­pro­tein (GP) IIb/IIIa, a fibrino­gen and von Wille­brand fac­tor bind­ing mem­brane recep­tor, has an impor­tant role in plate­let aggre­ga­tion. A com­mon leu­cine33-pro­line poly­mor­phism (PlA1/A2) of the gene encod­ing the GP IIIa sub­unit is asso­ciat­ed with plate­let reac­tiv­ity and has been pro­posed as a risk fac­tor for ath­e­roth­rom­bot­ic dis­ease. The aim of this study was to inves­ti­gate the role of this poly­mor­phism for deep ­venous throm­bo­sis (DVT).
Meth­ods. We per­formed a case-con­trol study includ­ing 206 ­patients with doc­u­ment­ed DVT and a sex- and age-­matched group of 310 con­trol sub­jects. GP IIIa gen­o­types were deter­mined by restric­tion frag­ment anal­y­sis of amplim­ers con­tain­ing the poly­mor­phic site.
­Results. A1/A1, A1/A2 and A2/A2 gen­o­types were found in 67.0, 31.6 and 1.5% of ­patients and 72.3, 25.8 and 1.9% of con­trols (p=0.35), PlA2 ­allele fre­quen­cies were 0.17 in ­patients and 0.15 in con­trols (p=0.92). Odds ratio of the PlA2 ­allele for DVT was 1.21 (95% CI 0.85-1.71, p=0.29) and ­remained insig­nif­i­cant after adjust­ment for fac­tor V Leid­en and pro­throm­bin 20210A gen­o­types (1.22, 95% CI 0.86-1.75, p=0.27).
Con­clu­sions. Our data sug­gest that the PlA1/A2 poly­mor­phism of GP IIIa is not asso­ciat­ed with DVT.

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