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International Angiology 1999 September;18(3):193-7

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Cytokine patterns and the effects of a preoperative steroid treatment in the patients with abdominal aortic aneurysms

Komori K., Ishida M., Matsumoto T., Kume M., Ohta S., Takeuchi K., Onohara T., Sugimachi K.

From the Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan


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Back­ground. The aim of this study was to inves­ti­gate the cyto­kine pat­terns of ­patients with abdom­i­nal aor­tic aneu­rysms and the ­effects of pre­op­er­a­tive ster­oid admin­is­tra­tion on sur­gi­cal ­stress.
Meth­ods. From Jan­u­ary 1996 to ­August 1996, 20 con­sec­u­tive ­patients under­went an elec­tive recon­struc­tion of infra­ren­al abdom­i­nal aor­tic aneu­rysms. The ­patients were ran­dom­ly divid­ed into two ­groups con­sist­ing of a con­trol group (n=10) and a ster­oid group (n=10), in whom 1 g of meth­yl­pred­nis­o­lone was intra­ve­nous­ly admin­is­tered two hours ­before the oper­a­tion. Meas­ures. Inter­leu­kin-6 was seri­al­ly meas­ured and the per­i­op­er­a­tive param­e­ters includ­ing C-reac­tive pro­tein were com­pared ­between both the con­trol and the ster­oid ­groups.
­Results. The inter­leu­kin-6 val­ues in the ster­oid group imme­di­ate­ly after declamp­ing, as well as at one and three post­op­er­a­tive days were sig­nif­i­cant­ly lower than those in the con­trol group. C-reac­tive pro­tein val­ues at one post­op­er­a­tive day in the ster­oid group were also sig­nif­i­cant­ly lower than those in the con­trol group. In one ­patient with a rup­tured abdom­i­nal aor­tic aneu­rysm, the inter­leu­kin-6 val­ues were high­er than those in the ­patients under­go­ing elec­tive sur­gery through­out the study.
Con­clu­sions. These ­results thus sug­gest that pre­op­er­a­tive ster­oid admin­is­tra­tion using meth­yl­pred­nis­o­lone in ­patients with abdom­i­nal aor­tic aneu­rysms ­appears to ­reduce sur­gi­cal ­stress by decreas­ing cyto­kine ­release.

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