CASE REPORT   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2021 November;180(11):758-60

DOI: 10.23736/S0393-3660.19.04258-X

Copyright © 2019 EDIZIONI MINERVA MEDICA

lingua: Inglese

Clozapine-induced acute interstitial nephritis

Pedro RODRIGUES ✉, Inês FERREIRA, Sofia TAVARES, Verónica GUIOMAR, Vanessa CHAVES, Jorge ALMEIDA

Acute interstitial nephritis can result from drug’s hypersensitivity reaction. This paper describes the development of an acute interstitial nephritis in a 25 years-old woman treated for the last 7 weeks with clozapine for a psychiatric disorder. Fever, elevated inflammatory markers and acute kidney injury were identified, and renal biopsy confirmed the diagnosis of interstitial nephritis. Patient experienced complete recovery after clozapine withheld. Clozapine is a highly effective antipsychotic drug, but can it causes fatal agranulocytosis and its hematological toxicity is well documented. We report clozapine-induced acute interstitial nephritis as another serious side-effect, suggesting that renal function monitoring should be considered in patient under clozapine treatment.

KEY WORDS: Fever; Clozapine; Acute kidney injury; Nephritis, interstitial