REVIEW   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2021 September;180(9):464-73

DOI: 10.23736/S0393-3660.20.04538-6

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Italiano

Immunità innata come protezione dalle infezioni virali

Beniamino PALMIERI ^{1, 2}, Francesca GALOTTI ^{1, 3}, Vincenzo SORESI ^{1, 4}, Giovanni LAZZARONI ^{1, 5}, Paolo MILAN ^{1, 2}, Roberto OLIVI ^{1, 6}, Luigi MAIONE ^{1, 2, 7}, Elena TONINI ^{1, 8}, William PILLOSU ^{1, 9}, Giorgio ACCIARINI ^{1, 10}, Nicola ANTONUCCI ^{1, 11}, Cristina ZENDRINI ^{1, 12}, Paola CAMERONI ^{1, 13}, Vincenzo RAMPONI ^{1, 14}, Erus SANGIORGI ¹, Rodolfo INCARNATO ¹, Maria CILLA ¹, Marcella BRIZZI ¹, Raffaele LUCÀ ¹, Ubayd IASHIR ¹, Anna ASPIRO ^{1, 15}, Vincenzo D’ONOFRIO ^{1, 16}, Fabrizio PEDRABISSI ^{1, 17}, Paolo Martino ALLEGRI ^{1, 18}, Simona RIVERA ^{1, 19}, Barbara RUSSO ¹, Alberto DALLARI ^{1, 20}, Giovanni BORRONI ^{1, 21}, Alessandro CASADEI ^{1, 22}, Gilberto DISTEFANO ¹, Giuseppe GALASSO ^{1, 23}, Marisa NICOLINI ¹, Maria VADALÀ ^{1, 2} ✉

¹ Medico Cura Te Stesso Onlus, Modena, Italy; ² Network del Secondo Parere, Modena, Italy; ³ Department of Anesthesia, Resuscitation, Intensive Care and Pain, University of Turin, Turin, Italy; ⁴ Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy; ⁵ Private Practitioner, Brescia, Italy; ⁶ Private Practitioner, Modena, Italy; ⁷ Private Practitioner, Cernusco sul Naviglio, Milan, Italy; ⁸ Private Practitioner, Gussago, Brescia, Italy; ⁹ Private Practitioner, Modena, Italy; ¹⁰ Private Practitioner, Civitanova Marche, Macerata, Italy; ¹¹ Biomedical Center for Autism Research and Treatment, Bari, Italy; ¹² Private Practitioner, Verona, Italy; ¹³ Private Practitioner, Castelnuovo Rangone, Modena, Italy; ¹⁴ Private Practitioner, Cento, Ferrara, Italy; ¹⁵ Private Practitioner, Modena, Italy, 16 Private Practitioner, Manfredonia, Foggia, Italy; ¹⁷ Private Practitioner, Finale Emilia, Modena, Italy; ¹⁸ Private Practitioner, Due Carrare, Padova, Italy; ¹⁹ Private Practitioner, Torino, Italy; ²⁰ Casa di Cura Polispecialistica Villa Verde, Reggio Emilia, Italy; ²¹ Anestesia e Rianimazione ASUR 9 Macerata, Macerata, Italy; ²² Private Practitioner, Mestre, Venezia, Italy; ²³ Private Practitioner, Alzano Lombardo, Bergamo, Italy

Adequate preventive specific and unspecific and therapeutic procedures are urgently required for the new incoming generation of viruses; some strategies approached the infections with chemotherapies adopted from previous antiviral programs or with off label drugs. The optimal goal would be to practice a widespread treatment safe, effective, sustainable, cheap as much as possible. The enhancement of innate immunity defenses and the support of the trained immunity are very helpful aside of the incoming vaccines. Innate immunity is the most ancient ready and quick defense against pathogens of al the living species: it commits phagocytic cells to directly get rid of the infectious agents, while the trained immunity is expressed by the adaptive immunity a late evolutionary phase (2 million years after the innate one): the antibodies producing immunological memory is usually tailored against specific antigens but can be expanded eliciting an immune response against other infecting noxa. This paper deals with the clinical history and revival of C. parvum, a killed commensal bacterium located in the sebaceous glands with strong unspecific antitumoral and antiviral innate immunity enhancing properties that can profitably be updated in hazardous infectious emergencies.

KEY WORDS: Coronavirus; SARS-CoV-2; COVID-19; Propionibacterium acnes