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ORIGINAL ARTICLE
Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 October;178(10):829-33
DOI: 10.23736/S0393-3660.18.03973-6
Copyright © 2018 EDIZIONI MINERVA MEDICA
lingua: Inglese
Correlation between pulse pressure and urinary albumin excretion in type 2 diabetic patients without microalbuminuria
Seydahmet AKİN 1 ✉, Zeki AYDİN 2, Ozlem CAKİR 1, Sinan KAZAN 1
1 Department of Internal Medicine, Dr. Lutfi Kirdar Kartal Training and Research Hospital, University of Health Sciences, Istanbul, Turkey; 2 Department of Nephrology, Darica Farabi Training and Research Hospital, Kocaeli, Turkey
BACKGROUND: Urinary albumin excretion is known to be associated with hypertension in type 2 diabetic patients. In many studies, a strong relation has been found between urinary albumin excretion and pulse pressure In this study, we aimed to investigate the relationship between urinary albumin excretion and pulse pressure in type 2 diabetic patients without microalbuminuria.
METHODS: Nonmicroalbuminuric type 2 diabetic patients were examined retrospectively. Demografic, laboratory data, urinary albumin excretion, blood pressure and pulse pressure measurements were obtained from whole patients.
RESULTS: A total of 588 patients (70.1%, female) were included in the study. The mean age was found to be 57.2±9.7 years. It was found that 37.4% (N.=220) of the patients were in the group with a PP of ≤46 mmHg (group 1), 40.8% (N.=240) were in the group with a PP of 46-56 mmHg (group 2) and 21.8% (N.=128) were in the group with a PP of ≥56 mmHg (group 3). There was a significant correlation (r=0.458) between pulse pressure and urinary albumin excretion independent of systolic, diastolic, or mean blood pressure levels among nonmicroalbuminuric patients with type 2 diabetes mellitus.
CONCLUSIONS: Pulse pressure may be a sign of progression to microalbuminuria. Increased pulse pressure may be used as a risk factor for development of diabetic nephropathy.
KEY WORDS: Albuminuria; Blood pressure; Diabetic nephropathies; Diabetes mellitus, type 2