ORIGINAL ARTICLE   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 October;178(10):775-80

DOI: 10.23736/S0393-3660.18.03958-X

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Significant reduction of T3 hormone and increase in the occurrence of non-thyroid illness syndrome in ovarian cyst and polycystic ovary syndrome patients

Foad ALZOUGHOOL ¹ ✉, Manar ATOUM ¹, Huda AL HOURANI ², Rana ABDELQADER ¹, Hani MASALHA ³, Abdel-Rahman ALKHARABSHEH ³, Aymen ABU-AWAD ⁴

¹ Department of Laboratory Medical Sciences, Faculty of Allied Health Sciences, The Hashemite University, Zarqa, Jordan; ² Department of Nutrition, Faculty of Allied Health Sciences, The Hashemite University, Zarqa, Jordan; ³ Department of Gynecology and Oncology, Prince Hamza Hospital, Amman, Jordan; ⁴ GenoLab Medical Sciences, Amman, Jordan

BACKGROUND: The relationship between the thyroid and ovarian pathophysiology is a subject of debate. Despite the fact that effects of hypothyroidism and hyperthyroidism on either polycystic ovarian syndrome (PCOS) or ovarian cyst have been clearly demonstrated, there is no sufficient data on the relationship between those ovarian disorders within the normal range of thyroid function (euthyroidism). This study aims to investigate the thyroid gland function hormones T3, T4, and TSH in women suffering from PCOS or the ovarian cyst within euthyroidism.
METHODS: The present study was a case-control study enrolled 174 women within reproductive age (18-45 years), include 58 patients with PCOS, 57 patients with an ovarian cyst, and 59 healthy women as control, all study subjects were among euthyroidism. We assessed the thyroid function by measuring the serum levels of TSH, Free T3 (FT3), and Free T4 (FT4) hormones using electrochemiluminescence immunoassay (ECLIA).
RESULTS: The results showed a significant reduction in FT3 and FT4 serum levels with no difference in follicle-stimulating hormone serum level in both PCOS and ovarian cyst patients compared to healthy control. Among euthyroid PCOS patients (15.5%) of patients were with non-thyroidal illness syndrome (NTIS), while among euthyroid ovarian cyst patients (45.6%) were with NTIS compared to none of the control was with NTIS.
CONCLUSIONS: Our study provides data for the first time on the possible occurrence of NTIS in PCOS and ovarian cyst. The prevalence of NTIS in the ovarian cyst is higher than PCOS. It is also suggested that measurements of thyroid hormones concentration could be useful for patients with PCOS or ovarian cyst and might be worthiest to do further research on T3 hormone therapeutics effect.

KEY WORDS: Polycystic ovarian syndrome; Ovarian cysts; Endocrine system; Thyroid gland; Hypothyroidism; Euthyroid sick syndrome