ORIGINAL ARTICLE   

Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 July-August;178(7-8):515-20

DOI: 10.23736/S0393-3660.18.03875-5

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Paraoxonase 1 and HDL functionality in 5-10 years duration of type 2 diabetes mellitus with diabetic foot

Mukund R. MOGAREKAR ✉, Seema S. KALE

Department of Biochemistry, SRTR Govt. Medical College, Ambajogai, India

BACKGROUND: Diabetic foot ulcerations have been extensively reported as vascular complications of diabetes mellitus Poor diabetic control is strongly associated with an increase in lipid peroxides. Present study aims to find the HDL functionality, PON 1 activity & lipid hydroperoxides in type 2 diabetes mellitus and diabetic foot patients and impact of severity of diabetes mellitus on HDL functionality.
METHODS: 30 patients of diabetes mellitus without complication and 30 patients of diabetic foot as representative of diabetic complication were selected as cases and compared with 30 healthy controls, for fasting plasma glucose, PON1 activity, HDL cholesterol levels and HDL functionality.
RESULTS: HDL functionality was significantly reduced in diabetic foot patients as compared with diabetics and control. PON1 activity decreased significantly in diabetic foot than diabetes mellitus patients & controls. Lipid hydroperoxides levels were increased significantly in diabetic foot patients than diabetics & controls. HDL function correlated positively with PON1 activity (r=0.668) & negatively with lipid hydroperoxides (r=-0.660). P value was set < 0.05 for all study parameters.
CONCLUSIONS: Serial measurements of PON1 arylesterase activity, lipid hydroperoxides and HDL functionality can be important to know acceleration of diabetic foot in type 2 diabetes mellitus.

KEY WORDS: Aryldialkylphosphatase; Cholesterol, HDL; Diabetes mellitus, type 2; Diabetic foot