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Gazzetta Medica Italiana - Archivio per le Scienze Mediche 2019 January-February;178(1-2):36-43

DOI: 10.23736/S0393-3660.17.03707-X

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Effect of ultramarathon race on liver and skeletal muscle biomarkers in recovery period

Kyung-A SHIN 1, Jaeki AHN 2, Jin Ho YOON 3, Yongbum PARK 2, Young-Joo KIM 4

1 Department of Clinical Laboratory Science, Shinsung University, Chungnam, South Korea; 2 Department of Rehabilitation Medicine, College of Medicine, Sanggye-Paik Hospital, Inje University, Seoul, South Korea; 3 Department of Sport and Leisure Studies, Far East University, Chungbuk, South Korea; 4 Department of Exercise Rehabilitation Welfare Soojung Campus, Sungshin University, Seoul, South Korea



BACKGROUND: To examine the changes in liver and skeletal muscle biomarkers during the recovery period of an ultramarathon race.
METHODS: Blood samples were collected and analyzed before running (pre-race), immediately after (100 km), and at 1, 3, and 5 days after completing an ultramarathon race.
RESULTS: Creatine kinase and lactate dehydrogenase levels were significantly higher at 100 km and at 1, 3, and 5 days post-race than at pre-race. They were lower at 5 days post-race than at 100 km and at 1 and 3 days post-race (P<0.05). Aspartate aminotransferase and alanine aminotransferase levels were significantly higher at 100 km and at 1, 3, and 5 days post-race than at pre-race, and were significantly lower at 3 days post-race than at 1 day post-race (P<0.05). White blood cell counts were significantly higher at 100 km and 1 day post-race than at pre-race, and significantly lower at 1 and 3 days post-race than at 100 km. Also, the level was significantly lower at 5 days post-race than at 100 km and at 1 and 3 days post-race (P<0.05). Hs-CRP levels were significantly higher at 100 km and at 1, 3, and 5 days post-race than at pre-race, while the level was significantly lower at 5 days post-race than at 100 km and at 1 and 3 days post-race (P<0.05).
CONCLUSIONS: An 100-km ultramarathon may cause temporary deterioration of liver function and an acute inflammatory response, which recover to normal status by the fifth days of recovery, due to severe muscle damage


KEY WORDS: Running - Creatine kinase - Aspartate aminotransferases - Bilirubin - Liver

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