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Gazzetta Medica Italiana Archivio per le Scienze Mediche 2018 January-February;177(1-2):14-9

DOI: 10.23736/S0393-3660.17.03484-2

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Immunohistochemical profile of breast cancer in young patients receiving care in a charity hospital in Brazil

Danielle CHAMBÔ 1, Janine NUNES MOULIN de MORAES 2, Laís COIMBRA CREMASCO TAVARES 2, Yara TRIGO MARTINEZ 2 , Antônio CHAMBÔ FILHO 2

1 Department of Breast Surgery, Santa Casa de Misericórdia Hospital, Vitória, Brazil; 2 Department of Obstetrics and Gynecology, Santa Casa de Misericórdia Hospital, Vitória, Brazil


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BACKGROUND: Although breast cancer is responsible for the greatest number of cancer-related deaths in women in Brazil, the diagnosis is rare in young women, with such patients accounting for 2-5% of all cases of breast cancer in the country. This study described the immunohistochemical profile of breast cancer in young women seen in a referral charity hospital in Vitória, the capital city of the state of Espírito Santo.
METHODS: This was a retrospective, descriptive study involving a sample of 56 female patients of 40 years of age or less diagnosed with in situ or invasive breast cancer between January 2009 and December 2015. Patients were selected for analysis following a search of 500 electronic patient records and anatomical pathology reports stored in the archives of this institute.
RESULTS: The most prevalent subtype of breast cancer in this population was the luminal A subtype (26.8%), followed by the triple-negative subtype (17.9%). The most common histological type was invasive ductal carcinoma (78.6%). These results corroborate the findings of several previous studies.
CONCLUSIONS: Since prognosis is poorer for patients with triple-negative tumors, immunohistochemical analysis of the hormone receptor profile is vital in breast cancer care, permitting treatment to be individualized and resulting in a greater cure rate and a longer disease-free interval. Further studies are required to establish better means of secondary prevention for patients in this age group.


KEY WORDS: Breast neoplasms - Young adult - Adult - immunohistochemistry - Progesterone receptors - Estrogen receptors - HER-2 protein

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