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Original Article   

Minerva Gastroenterology 2022 May 05

DOI: 10.23736/S2724-5985.21.03066-7


lingua: Inglese

Treatment with phosphatidylcholine of patients with non-alcoholic fatty liver disease: a prospective pilot study

Ludovico ABENAVOLI 1 , Roman MYAZIN 2, Sharmila FAGOONEE 3, Pietro CINAGLIA 1, Francesco LUZZA 1, Rinaldo PELLICANO 4, Dmitry EMELYANOV 2

1 Department of Health Sciences, University Magna Graecia, Catanzaro, Italy; 2 Department of internal diseases of the Federal State Budgetary Educational Institution of Higher Education Volgograd State Medical University of the Ministry of Health of the Russian Federation, Volgograd, Russia; 3 Institute for Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Centre, Turin, Italy; 4 Unit of Gastroenterology, Città della Salute e della Scienza-Molinette Hospital, Turin, Italy


BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is characterized by a complex clinical picture that includes non-alcoholic steatohepatitis and cirrhosis. In the last decades, several studies have shown that NAFLD increases the risk of cardiovascular diseases. In a prospective pilot study, the benefit of treatment with phosphatidylcoline in NAFLD patients has been assessed.
METHODS: Thirty patients with NAFLD were enrolled. All received treatment with phosphatidylcoline (Essentiale® Forte N) 300 mg capsules, administered 2 at time orally, 3 times a day with meals for three months. The clinical and laboratory parameters before and after treatment were compared.
RESULTS: After the administration of Essentiale® Forte N the level of alanine aminotransferase (ALT) decreased by 59.6% (p<0.05) and that of aspartate transaminase (AST) decreased by 75.4% (p<0.05). Moreover, after treatment, an increase in antioxidant enzymes superoxide dismutase by 48% (p<0.05) and glutathione peroxidase by 48.1% (p<0.05) was observed.
CONCLUSIONS: The results of the study indicate that treatment with Essentiale® Forte N for 3 months was associated with a significant decrease in transaminase levels, in the activity of lipid peroxidation markers and an increase in the level of antioxidant enzymes.

KEY WORDS: Antioxidant; Cardiovascular diseases; Diagnosis; Treatment

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