Minerva Gastroenterology 2021 Jul 19

DOI: 10.23736/S2724-5985.21.02888-6

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Histology of ibd and related colitides in the elderly

Giuseppe LEONCINI ¹ ✉, Luca REGGIANI-BONETTI ², Gloria SIMONCELLI ³, Vincenzo VILLANACCI ³

¹ Pathology Unit, ASST del Garda, Desenzano del Garda, Brescia, Italy; ² Pathology Unit, Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy; ³ Institute of Pathology Spedali Civili, Brescia Italy

Inflammatory bowel disease (IBD) are chronic relapsing diseases, affecting both children and adults with a life-long duration. An increased co-morbidity gives raise to fragility in the elderly. In this regard it should take into account that several non-IBD colitides may mimic both ulcerative colitis and Crohn's disease. Moreover, chronic diseases represent a clinical challenge, mostly about treatment effectiveness.
Finally, it is worth noting that patients with long-standing diseases - and elderly patients among them - have an increased malignancy risk when compared to general (non-IBD) population. Our paper aims to review the three main histological topics that play a role in the clinical management of IBD in the elderly, namely differential diagnosis, mucosal healing and IBD-associated dysplasia.

KEY WORDS: IBD, Ulcerative colitis; Crohn’s disease; Non-IBD colitis; Dysplasia