Home > Riviste > Minerva Gastroenterology > Fascicoli precedenti > Articles online first > Minerva Gastroenterology 2021 May 12

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo
Share

 

 

Minerva Gastroenterology 2021 May 12

DOI: 10.23736/S2724-5985.21.02910-7

Copyright © 2021 EDIZIONI MINERVA MEDICA

lingua: Inglese

Probiotics and gut health

Emidio SCARPELLINI 1, 2 , Martina BASILICO 1, Emanuele RINNINELLA 3, Florencia CARBONE 2, Jolien SCHOL 2, Carlo RASETTI 1, Ludovico ABENAVOLI 4, Pierangelo SANTORI 1

1 Clinical Nutrition Unit, and Internal Medicine Unit, Madonna del Soccorso General Hospital, San Benedetto del Tronto, Ascoli Piceno, Italy; 2 T.A.R.G.I.D., Gasthuisberg University Hospital, KULeuven, Leuven, Belgium; 3 Clinical Nutrition Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy; 4 Department of Health Sciences, University Magna Graecia, Campus Salvatore Venuta, Catanzaro, Italy


PDF


BACKGROUND: Gut microbiota is a complex ecosystem of bacteria, viruses, archea, protozoa and yeasts in our intestine. It has several functions maintaining human body equilibrium. Microbial “ dysbiosis “ can be responsible for several gastrointestinal diseases.
METHODS: to build a narrative review we performed a Pubmed, Medline, EMBASE search for English language papers, reviews, meta-analyses, case series, and randomized controlled trials (RCTs) by keywords and their associations: gut microbiota, dysbiosis, gastrointestinal diseases, probiotics.
RESULTS: gut microbiota is altered in several gastrointestinal diseases with very different pathophysiology. They range from multi-factorial diseases such as irritable bowel syndrome (IBS), non-alcoholic fatty liver disease (NAFLD) and gastric and colorectal cancers, immunemediated such as celiac disease, inflammatory bowel diseases (IBD), antibioticrelated such as Clostridium Difficile infection (CDI). Microbial dysbiosis re-modulation by probiotics is feasible and safe in some of them.
CONCLUSIONS: gut microbial dysbiosis is statistically associated with several gastro-intestinal diseases, affecting their pathophysiology. Its reverse by probiotics has some promising evidences of efficacy.


KEY WORDS: Gut microbiota; Dysbiosis; Probiotics; Gastrointestinal diseases

inizio pagina