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ORIGINAL ARTICLE   Free accessfree

Minerva Gastroenterologica e Dietologica 2020 March;66(1):35-40

DOI: 10.23736/S1121-421X.19.02650-3

Copyright © 2019 EDIZIONI MINERVA MEDICA

lingua: Inglese

Effectiveness of a nutraceutical supplement containing highly standardized perilla and ginger extracts in patients with functional dyspepsia

Francesco DI PIERRO 1 , Maurizio GIOVANNONE 2, Mariella SAPONARA 3, Leandro IVALDI 4

1 Velleja Research, Milan, Italy; 2 Unit of Gastroenterology, San Camillo de Lellis Hospital, Rieti, Italy; 3 ASL CN1, Cuneo, Italy; 4 Department of Digestive Endoscopy, Ceva Hospital, Ceva, Cuneo, Italy



BACKGROUND: In Western countries functional dyspepsia (FD) has a prevalence of 10-20% among adults and although many drugs are currently available for use within clinical practice, FD remains an important challenge for physicians. Recently, food supplements that are ginger-based, along with other botanicals, have been proposed to be a possible natural alternative to pharmaceutical drugs to empirically counteract the symptoms of FD.
METHODS: We have therefore retrospectively analyzed the efficacy and safety profiles of a nutraceutical containing, in addition to a highly standardized ginger root extract, a multi-fractionated botanical obtained from Perilla frutescens leaf containing an innovative bouquet of compounds, including hydrophilic polyphenols and the lipophilic terpenoid perilla ketone.
RESULTS: The results of our single-group study, obtained from patients with a diagnosis of FD who were treated with the perilla/ginger nutraceutical, demonstrated a good efficacy profile, with a significant reduction observed in nearly all evaluated symptoms (epigastric pain, heartburn, gastric reflux, nausea, borborygmi, early satiety, diarrhea/constipation) starting from the first week of treatment that was further improved after 2 weeks. The treatment was well tolerated with very mild side effects (flatulence, meteorism, gastric burning, difficulty in falling asleep) lasting 3-4 days, which disappeared without stopping the treatment.
CONCLUSIONS: Despite all the limitations of our pragmatic study, we believe that the perilla and ginger supplement we have used can be considered a valid tool for an empirical approach to treating patients with FD, especially when a non-conventional drug treatment is preferable to the patient and considered suitable by the physician.


KEY WORDS: Perilla frutescens; Pain; Dyspepsia

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