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Minerva Gastroenterologica e Dietologica 2014 December;60(4):263-8


lingua: Inglese

Benefit of supplements in functional dyspepsia after treatment of Helicobacter pylori

Pellicano R. 1, Ribaldone D. G. 1, Saracco G. M. 2, Leone N. 3, De Angelis C. 1, Arrigoni A. 1, Morello E. 4, Sapone N. 1, Cisarò F. 5, Astegiano M. 1

1 Department of Gastroenterology and Hepatology, San Giovanni Battista (Molinette) Hospital, Turin, Italy; 2 Department of Gastroenterology, San Luigi Hospital, Orbassano, Turin, Italy; 3 Division of Gastroenterology, Gradenigo Hospital, Turin, Italy; 4 Division of Gastroenterology, Chivasso Hospital, Chivasso, Turin, Italy; 5 Division of Gastroenterology, Regina Margherita Hospital, Turin, Italy


AIM: Functional dyspepsia, though benign, leads to deterioration of the quality of life and high costs for healthcare systems. The optimal therapy for functional dyspepsia is still to be defined because of its multifactorial pathogenesis. In an open multicentric study of patients with functional dyspepsia, we prospectively evaluated the benefit of treatment with a food supplement composed of sodium alginate, carbonate calcium, pineapple, papaya, ginger, α-galactosidase and fennel (Perdiges, Bioten Snc, Turin, Italy).
METHODS: Ninety-one consecutive patients were included, suffering from functional dyspepsia, who had been previously submitted to therapy to eradicate the infection from Helicobacter pylori (H. pylori) and were waiting to perform the Urea Breath Test (UBT). The primary goal was to establish the percentage of patients who continued to abstain from proton pump inhibitors (PPI) as they waited to carry out the UBT, differentiating between patients who were treated (N.=55) with Perdiges and those who were not (N.=36). Our secondary goal was to document the differences within the 2 groups in terms of symptoms perceived between the start and end of the observation period. The wellness reported, during or in absence of treatment with Perdiges, was evaluated by the use of the VAS scale (Visual Analogical Scale) completed before the start of the treatment and after 30 days.
RESULTS: All the patients treated with Perdiges (55/55, 100%) and 31/36 (86.1%) patients who were not (P=0.008) continued to abstain from PPI in the period awaiting the UBT. The VAS scale of those who took Perdiges improved on average by 1.78 points versus a worsening of 0.08 points of those who did not take it (P<0.0001). Furthermore, while among those who took Perdiges there was a statistically significant improvement (P<0.0001) in the VAS scale, between the baseline and the end of treatment, a worsening of 0.08 points (P=0.78) was noticed among the patients who did not take it.
CONCLUSION: Perdiges is significantly effective in the period following treatment to eradicate the infection from H. pylori in patients with functional dyspepsia. This allows to reduce the need to use antisecretive drugs. Further randomised studies, with wide ranging case histories, must assess its long-term efficacy.

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