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MINERVA GASTROENTEROLOGICA E DIETOLOGICA

Rivista di Gastroenterologia, Nutrizione e Dietetica


Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


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Minerva Gastroenterologica e Dietologica 2018 Feb 19

DOI: 10.23736/S1121-421X.18.02481-9

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Benign and malignant gastroduodenal diseases associated with Helicobacter pylori: a narrative review and personal remarks in 2018

György M. BUZÁS

Department of Gastroenterology, Ferencváros Health Centre, Budapest, Hungary


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The subject of Helicobacter pylori continues to elicit worldwide interest in many research fields. Epidemiological data suggest that the prevalence of the infection is decreasing in Western/developed countries and even in some developing regions, but this is masked by the high prevalence in the most populous regions. Chronic gastritis, caused invariably by the bacterium, was again classified in Kyoto and Helicobacter pylori-associated gastritis was included as a distinct entity. The prevalence of peptic ulcers is decreasing, but bleeding ulcers are a challenging problem, with stable mortality levels even in the endoscopic era. With the extended use of endoscopy, gastric polyps have become more prevalent: some are associated with the infection, some are not. Autoimmune and Helicobacter-induced gastritis can share common pathogenetic mechanisms. Gastric cancer is ranked highly on mortality lists worldwide. Its surgical treatment has registered some progress though. Little, if any improvement has been achieved in the medical treatment of advanced gastric cancer. With proper organization, gastric cancer seems a preventable disease. In spite of many guidelines, the Pan-European registry of Helicobacter pylori management shows that eradication rates obtained in many places are suboptimal. A new therapeutic regimen was compiled with promising pilot results. The results obtained with vonaprazan are limited to Asia. New avenues of both antibiotic and non-antibiotic treatments are expected to accelerate the eradication of this ulcerogenic and carcinogenic bacterium.


KEY WORDS: Dyspepsia - Gastric cancer - Gastric polyp - Gastritis - Helicobacter pylori - Lymphoma - Pan-European registry of Helicobacter pylori management

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Publication History

Article first published online: February 19, 2018
Manuscript accepted: February 15, 2018
Manuscript received: February 7, 2018

Per citare questo articolo

Buzás GM. Benign and malignant gastroduodenal diseases associated with Helicobacter pylori: a narrative review and personal remarks in 2018. Minerva Gastroenterol Dietol 2018 Feb 19. DOI: 10.23736/S1121-421X.18.02481-9

Corresponding author e-mail

drbgym@gmail.com