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MINERVA GASTROENTEROLOGICA E DIETOLOGICA

Rivista di Gastroenterologia, Nutrizione e Dietetica


Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


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Minerva Gastroenterologica e Dietologica 2017 Dec 14

DOI: 10.23736/S1121-421X.17.02463-1

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Indications for and outcomes of liver transplantation in patients with alcohol-associated liver disease (AUD)

Paulina K. PHILLIPS 1, 2, Matthew W. CALDIS 2, Alexander D. HRISTOV 2, Alexander S. LEE 2, Michael R. LUCEY 1 2

1 Division of Gastroenterology and Hepatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; 2 Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA


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The manufacture and consumption of alcohol are ubiquitous and as old as time. Alcohol use disorder (AUD) is defined as a problematic pattern of alcohol use leading to clinically significant impairment. The physical injuries that result from excessive alcohol consumption are varied including end-organ damage to liver (alcohol-associated liver disease or ALD), pancreas, brain and heart, and systemic consequences including several forms of cancer. Liver transplantation (LT) remains the treatment of last resort for life-threatening liver disease. LT provides a valuable magnifying glass under which to examine the complex interactions between social drinking, AUD, and ALD. ALD is the second most frequent indication for LT in the US (data of 2015). We review the current data on evaluation of patients with AUD and ALD for liver transplantation; on the significance of abstinence from alcohol in patient selection and pre- and post-LT management. We discuss monitoring for relapse prior to and after LT. Finally, we look at outcomes, first from the perspective of impact on the allograft and then the perspective of maintaining the health of the LT patient with AUD, which includes management of addiction.

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Publication History

Article first published online: December 14, 2017
Manuscript accepted: December 6, 2017
Manuscript received: December 6, 2017

Per citare questo articolo

Phillips PK, Caldis MW, Hristov AD, Lee AS, Lucey MR. Indications for and Outcomes of Liver Transplantation in Patients with Alcohol- associated Liver Disease (AUD). Minerva Gastroenterol Dietol 2017 Dec 14. DOI: 10.23736/S1121-421X.17.02463-1

Corresponding author e-mail

mrl@medicine.wisc.edu