Home > Riviste > Minerva Gastroenterologica e Dietologica > Fascicoli precedenti > Minerva Gastroenterologica e Dietologica 2017 December;63(4) > Minerva Gastroenterologica e Dietologica 2017 December;63(4):319-26

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Publication history
Estratti
Per citare questo articolo

MINERVA GASTROENTEROLOGICA E DIETOLOGICA

Rivista di Gastroenterologia, Nutrizione e Dietetica


Indexed/Abstracted in: CAB, EMBASE, PubMed/MEDLINE, Scopus, Emerging Sources Citation Index


eTOC

 

ORIGINAL ARTICLE  


Minerva Gastroenterologica e Dietologica 2017 December;63(4):319-26

DOI: 10.23736/S1121-421X.17.02411-4

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Comparison of two methods for the in-vivo diagnosis of Helicobacter pylori infection using a tablet of 13C-urea

Daniela GILARDI 1, Gionata FIORINO 1, Federica FURFARO 1, Marina F. ALFIERI 1, Ilaria ORLANDI 1, Mariangela ALLOCCA 1, Silvio DANESE 1, 2

1 IBD Center, Humanitas Clinical and Research Center, Rozzano, Milan, Italy; 2 Department of Biomedical Sciences, Humanitas University, Rozzano, Milan, Italy


PDF  


BACKGROUND: The urea Breath-test is a widely-used method to detect the presence of Helicobacter pylori (HP) infection. Recently, new technologies were introduced, to obtain an immediate test result by continuous breath samples analysis after labeled urea intake. The total test duration is shorter than 20 minutes.
METHODS: The study compared two diagnostic methods requiring the administration of EXPIROBACTER® (Sofar SpA, Trezzano Rosa, Milan, Italy) 100 mg as a source of labeled urea. Subjects with clinical indication to urea breath test for H. pylori were enrolled. This study was designed to directly compare the accuracy of urea breath test performed with both the classic method and BreathID® (Exalenz Bioscience, Inc., Manasquan, NJ, USA). Each patient simultaneously underwent to both tests, to measure the concordance between the results (positive or negative test), minimizing the risks of differences related to the intra- and inter-individual variability.
RESULTS: Forty-six subjects were enrolled. Forty-one patients (91.1%) were found negative with both methods and 5 (10.1%) were positive for H. pylori infection in both tests. Correlation between the two methods was excellent (κ=1.00). BreathID® was significantly preferred by patients, with a 7.83 (95% CI: 3.35 to 12.30, P=0.001) difference in mean patient satisfaction, measured by a Visual Analogue Scale (VAS). No adverse event was observed.
CONCLUSIONS: Correlation between the two methods was excellent. Moreover, the patient satisfaction, measured by VAS, showed a significantly greater acceptance of BreathID® method. This study support the use of a product containing 13C-urea 100 mg and citric acid for immediate determination of HP infection by urea breath test performed with BreathID®.


KEY WORDS: Breath tests - Urea - Helicobacter pylori

inizio pagina

Publication History

Issue published online: September 18, 2017
Manuscript accepted: April 10, 2017
Manuscript received: April 10, 2017

Per citare questo articolo

Gilardi D, Fiorino G, Furfaro F, Alfieri MF, Orlandi I, Allocca M, et al. Comparison of two methods for the in-vivo diagnosis of Helicobacter pylori infection using a tablet of 13C-urea. Minerva Gastroenterol Dietol 2017;63:319-26. DOI: 10.23736/S1121-421X.17.02411-4

Corresponding author e-mail

sdanese@gmail.com