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Italian Journal of Emergency Medicine 2022 April;11(1):5-9

DOI: 10.23736/S2532-1285.22.00134-3

Copyright © 2022 THE AUTHORS

This is an open access article distributed under the terms of the CC BY-NC-ND 4.0 license which allows users to copy and distribute the manuscript, as long as this is not done for commercial purposes and further does not permit distribution of the manuscript if it is changed or edited in any way, and as long as the user gives appropriate credits to the original author(s) and the source (with a link to the formal publication through the relevant DOI) and provides a link to the license.

lingua: Inglese

Thrombotic aspects of SARS-CoV-2 infection: indications for treatment

Luigi PETRAMALA 1, 2 , Antonello ROSA 2, Adriana SERVELLO 2, Daniele PASTORI 2, Luca MARINO 2 Sapienza MEU Group 

1 Department of Translational and Precision Medicine, Sapienza University, Rome, Italy; 2 Department of Emergency Area, Umberto I Polyclinic Hospital, Rome, Italy

Several studies highlighted the importance of thrombotic complications during early phases of acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) as well as long-term complications, until responsible for the high mortality observed in SARS-CoV-2 infection. The relationship “increased thrombotic risk and COVID-19 infection” justified further researchers, especially those undergoing hospitalization for severe COVID-19 infection, presented thrombotic complications during follow-up, after hospital discharge and apparent healing. It was highlighted that SARS-CoV-2 infection mainly affects the upper airways, the access of the virus in the humans, while the complications are systemic, secondary to extensive endothelial damage, with consequent systemic activation of the immune system and of pro-thrombotic system. Recent data confirm that prophylactic antithrombotic treatment is useful in hospitalized patients, and in selected cases it is useful at high therapeutic dose.

KEY WORDS: SARS-CoV-2; COVID-19; Thrombosis; Endothelium

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