Home > Riviste > Giornale Italiano di Dermatologia e Venereologia > Fascicoli precedenti > Articles online first > Giornale Italiano di Dermatologia e Venereologia 2020 Apr 29

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

 

Giornale Italiano di Dermatologia e Venereologia 2020 Apr 29

DOI: 10.23736/S0392-0488.20.06518-9

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Comparison of efficacy & safety of 30% hydrogen peroxide with 50% trichloroacetic acid in seborrheic keratosis: a randomized controlled study

Divya AGRAWAL, Mohammad ADIL , Syed S. AMIN, Mohd MOHTASHIM, Roopal BANSAL, Hera TABASSUM

Department of Dermatology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India


PDF


BACKGROUND: Seborrheic keratosis is a benign skin tumour. None of the common therapies is satisfactory. This study compared the efficacy of 30% hydrogen peroxide versus 50% trichloroacetic acid in treatment of seborrheic keratoses.
METHODS: This unblinded, comparative interventional study was conducted on 85 patients of seborrheic keratosis. Lesions were graded using physician’s lesion assessment (PLA) scale (0, clear; 1, nearly clear; 2 ≤1mm thick; 3 ≥1mm thick). Patients were randomly assigned into two groups: A and B. Five target seborrheic keratosis lesions with PLA score of three were selected in each patient. Group A was treated with 30% hydrogen peroxide and group B with 50% trichloroacetic acid. Both groups received treatment every week up to 5 weeks or till complete resolution of lesions. Clinical photographs of all patients were taken every 2 weeks.
RESULTS: Both the groups were comparable in terms of age and sex. At the end of 6 weeks, lesions were cleared completely in 41.8% of patients in group A and in 23.8% in group B. Mean PLA score decreased significantly in group A from 3 to 1.79 (40.3%) at 2 weeks and to 0.63 (79%) at 6 weeks (p <0.001). The decrease in PLA score in group B was 2.41 (19.7%) and 1.13 (62.3%) at 2, and 6 weeks respectively (p<0.001). Hydrogen peroxide produced greater clearance of seborrheic keratosis (p=0.017) than trichloroacetic acid. Also, no major adverse effects were observed in the two groups.
CONCLUSIONS: Application of 30% hydrogen peroxide appears to be more efficacious as compared to trichloroacetic acid (50%) for treatment of seborrheic keratosis.


KEY WORDS: Seborrheic keratosis; Hydrogen peroxide; Trichloroacetic acid

inizio pagina