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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Rivista di Dermatologia e Malattie Sessualmente Trasmesse


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2018 Mar 29

DOI: 10.23736/S0392-0488.18.05941-2

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Occurrence of Lyme disease infection in a non endemic area in Northern Italy

Sara G. RIMOLDI 1 , Stefania MERLI 2, Giovanna BESTETTI 2, Vania GIACOMET 3, Giuliana CISLAGHI 4, Romualdo GRANDE 1, Sergio SANZANI 5, Cristina PAGANI 1, Giusto TREVISAN 6, Eleonora DE FAVERI 5, Maria R. GISMONDO 1, Eva RUZIĆ-SABLJIĆ 7, on behalf of Exodes study group 

1 UOC Laboratorio di Microbiologia Clinica, Virologia e Diagnostica delle Bioemergenze, Azienda Socio Sanitaria Territoriale Fatebenefratelli-Sacco, Milano, Italy; 2 Dipartimento di Malattie Infettive, Azienda Socio Sanitaria Territoriale Fatebenefratelli-Sacco, Milano, Italy; 3 UO Pediatria, Azienda Socio Sanitaria Territoriale Fatebenefratelli-Sacco, Milano, Italy; 4 UO Neurologia, Azienda Socio Sanitaria Territoriale Fatebenefratelli-Sacco, Milano, Italy; 5 Dipartimento di Medicina Veterinaria, Università di Milano, Milano, Italy; 6 UO Dermatologia, Trieste, Italy; 7 Laboratory for Boreliosis and Leptospirosis, Università di Ljubljana, Ljubljana, Slovenia


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BACKGROUND: In Italy, the incidence of human tick borne disease has increased over the last decades. Since 2015 a multidisciplinary group has been established in Sacco Hospital for the management of the patients affected by Lyme Disease (LD). A retrospective evaluation (2015-2017) was performed for LD in non-endemic areas.
METHODS: Retrospective analysis of all 1000 samples for 800 patients screened for LD antibodies at the Sacco Hospital in 3 years (2015-2017). Revision of clinical et epidemiological patients data available and correlation with the serological results.
RESULTS: Among the 800 patients screened only 134 of them were diagnosed with borreliosis: 37 cases during 2015, 31 during 2016 and 66 during 2017. Localized Lyme disease was diagnosed of 134 cases (69%): in most of them (N=63) erythema migrans (EM) has been documented; in 37 out of 100 it was not possible to detect it. In only three cases, patients complained of different clinicalì symptoms such as headache, arm and facial pain respectively. 23 out of 144 cases (16%) showed a persistence of serological positivity and symptoms with osteomuscular involvement and fatigue, despite the therapy (Late Lyme disease). In that same study 11 out of 144 patients (7%) received a diagnosis of neuroborreliosis.
CONCLUSIONS: Our data reported an high percentage of Lyme Disease infection (19%) in non endemic area. The definition of a multidisciplinary working group and a clinical care pathway allowed a better clinical management of Lyme disease cases treated in Sacco Hospital, Milan.

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Publication History

Article first published online: March 29, 2018
Manuscript accepted: March 22, 2018
Manuscript received: February 3, 2018

Per citare questo articolo

Rimoldi SG, Merli S, Bestetti G, Giacomet V, Cislaghi G, Grande R et al; Exodes study group. Occurrence of Lyme disease infection in a non endemic area in Northern Italy. G Ital Dermatol Venereol 2018 Mar 29. DOI: 10.23736/S0392-0488.18.05941-2

Exodes study group

Spinello ANTINORI; Vittorio SALA; Katiuscia NAN; Francesca ROMERI; Marco FASAN; Gianfranco DEDIVITIS; Chiara ATZORI; Agostino ZAMBELLI; Riccardo GIORGI; Salvatore SOLLIMA

Corresponding author e-mail

sara.rimoldi@asst-fbf-sacco.it