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Giornale Italiano di Dermatologia e Venereologia 2018 Mar 26

DOI: 10.23736/S0392-0488.18.05897-2


lingua: Inglese

Is HERV-K and HERV-W expression regulated by mir-155 in Sézary syndrome?

Massimiliano BERGALLO 1 , Valentina DAPRÀ 1, Mauro NOVELLI 2, Marco RASSU 1, Paola MONTANARI 1, Ilaria GALLIANO 1, Pietro QUAGLINO 2, Maria T. FIERRO 2

1 Department of Public Health and Pediatric Sciences, University of Turin, Medical School, Turin, Italy; 2 Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy


BACKGROUND: According to the latest update, 2578 unique mature miRNAs are currently annotated in the human genome and participate in the regulation of multiple events, such as cellular proliferation or apoptosis. A previous study analyzing global miRNA expression patterns in GH cells (high HERV-K versus low) showed that two miRNAs (miR-663 and miR-638) are differentially regulated and exhibit expression parallel to that of HERV-K. The aim of this study was to evaluate HERV-K and -W pol gene and mir-155 expression in SS patients and possible relationship between them.
METHODS: The comparison between SS patients and healthy donor showed a significant difference in terms of mir-155 expression p=0.0003 as previously reported by our groups.
RESULTS: We demonstrated that HERV-K and -W pol gene expression was significantly higher in SS patients vs healthy donor as previously reported by our groups. Our correlation data suggest that miR-155 are not directly involved in regulating the HERVs.
CONCLUSIONS: Furthermore, further studies including other cohorts of pathology with mir-155 and HERVs involvement such as inflammatory diseases are needed to investigate the role of mir-155 in the cross-activations of HERVs.

KEY WORDS: HERV-K - HERV-W - mir155 - Sézary syndrome

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