Home > Riviste > Giornale Italiano di Dermatologia e Venereologia > Fascicoli precedenti > Articles online first > Giornale Italiano di Dermatologia e Venereologia 2018 Jan 24

ULTIMO FASCICOLO
 

ARTICLE TOOLS

Estratti
Per citare questo articolo

GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Rivista di Dermatologia e Malattie Sessualmente Trasmesse


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
Indexed/Abstracted in: EMBASE, PubMed/MEDLINE, Science Citation Index Expanded (SciSearch), Scopus
Impact Factor 1,311


eTOC

 

Giornale Italiano di Dermatologia e Venereologia 2018 Jan 24

DOI: 10.23736/S0392-0488.17.05819-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Gender differences in genital lichen sclerosus

Annarosa VIRGILI 1, Alessandro BORGHI 1 , Simone CAZZANIGA 2, 3, Anna DI LANDRO 2, Luigi NALDI 2, 4, Sara MINGHETTI 1, Maria T. FIERRO 5, Anna VERRONE 5, Marzia CAPRONI 6, Giuseppe MICALI 7, Valeria GASPARI 8, Manuela PAPINI 9, Vito DI LERNIA 10, Lerica GERMI 11, Giampiero GIROLOMONI 12, Anna BELLONI FORTINA 13, Serafinella P. CANNAVÒ 14, Roberta BILENCHI 15, Monica CORAZZA 1, on behalf of the GLS Italian Study Group

1 Sezione di Dermatologia e Malattie Infettive, Dipartimento di Scienze Mediche, Università degli Studi di Ferrara, Ferrara, Italy; 2 Centro Studi GISED-FROM, Bergamo, Italy; 3 Dermatology Department, Inselspital University Hospital, Bern, Switzerland; 4 UO di Dermatologia, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; 5 Dermosifilopatia 2, Azienda Ospedaliera Città della Salute e della Scienza di Torino, Turin, Italy; 6 Malattie Rare Dermatologiche e Immunopatologia Cutanea, U.O. Dermatologia I ASF-Università di Firenze, Florence, Italy; 7 UOC Dermatologia, P.O.G. Rodolico Azienda Ospedaliero-Universitaria Policlinico Vittorio Emanuele, Catania, Italy; 8 Dermatologia, Dipartimento di Medicina Specialistica, Diagnostica e Sperimentale, Università di Bologna, Bologna, Italy; 9 Clinica Dermatologica di Terni, Dipartimento di Specialità Chirurgiche e Biomediche, Università degli Studi di Perugia, Perugia, Italy; 10 Struttura Semplice di Dermatologia Immunologica e Pediatrica, Arcispedale Santa Maria Nuova, IRCCS Azienda Ospedaliera di Reggio Emilia, Reggio Emilia, Italy; 11 U.O.C. Dermatologia, Ospedale San Bortolo, Vicenza, Italy; 12 U.O. Dermatologia, Dipartimento di Medicina, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy; 13 Clinica Dermatologica, Dipartimento di Medicina, Azienda Ospedale Università di Padova, Padua, Italy; 14 Unità Operativa Complessa di Dermatologia, DAI di Medicine Specialistiche, A. O. U. Policlinico “Gaetano Martino”, Messina, Italy; 15 S.C di Dermatologia, Azienda Ospedaliera Universitaria Senese, D.A.I. Medicina Clinica e Scienze Immunologiche Applicate, Siena, Italy; 16 Unità Operativa di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Università di Brescia, Brescia, Italy; 17 UOSD Dermatologia Oncologica e Chirurgia delle Neoformazioni Cutanee, Azienda Ospedaliera “Sant’Anna e San Sebastiano”, Caserta, Italy; 18 Distretto n. 6 Ambulatori di Dermatologia, Azienda Sanitaria Locale Taranto, Taranto, Italy


PDF  


BACKGROUND: Studies specifically conducted to assess gender differences in genital lichen sclerosus (GLS) are not available. This multicenter study aimed to identify possible gender-related differences on GLS clinical features, history and course, through collecting data from a large mixed-sex sample of patients.
METHODS: This was a cross-sectional study on 729 subjects (53.8% females, 46.2% males) affected with GLS, consecutively observed within a network of 15 Italian dermatology units. The following information was specifically collected: clinical features and severity of symptoms related to GLS, extragenital involvement, previous therapies, diagnostic suspicion at referral, type of referring physicians, development of genital squamous-cell carcinoma (SCC).
RESULTS: Females complained of symptoms more frequent and severe than men; pallor and scarring-sclerosis-atrophy were the most frequent features without gender differences; itching- related signs were more frequent in females than in males as well as extragenital involvement; prior to receiving a definitive diagnosis, females received treatment more frequently than males; 40% of patients were referred with a misdiagnosis; the highest rate of correct suspected diagnosis at referral came from dermatologists than from other physicians; duration of the disease was found to predispose to SCC development.
CONCLUSIONS: Our findings highlighted several gender differences on clinical presentation and symptom profile of GLS. In spite of some characteristic features, misdiagnosis at referrals was frequent.


KEY WORDS: Genital lichen sclerosus - Gender differences - Clinical features - Symptoms - Therapy - Referral - Genital squamous-cell carcinoma

inizio pagina

Publication History

Per citare questo articolo

Virgili A, Borghi A, Cazzaniga S, Di Landro A, Naldi L, Minghetti S, et al; the GLS Italian Study Group. Gender differences in genital lichen sclerosus. . DOI: 10.23736/S0392-0488.17.05819-9

the GLS Italian Study Group

Corresponding author e-mail

alessandro.borghi@unife.it