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Rivista di Dermatologia e Malattie Sessualmente Trasmesse

Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 Nov 16

DOI: 10.23736/S0392-0488.17.05670-X


lingua: Inglese

Primary cutaneous B-cell lymphoma: narrative review of the literature

Vieri GRANDI 1 , Silvia ALBERTI VIOLETTI 2, Roberta LA SELVA 3, Stefano CICCHELLI 3, Chiara DELFINO 1, Paolo FAVA 3, Maria T. FIERRO 3, Alessandro PILERI 1, 4, Nicola PIMPINELLI 1, Pietro QUAGLINO 3, Emilio BERTI 2

1 Dermatology Unit, Department of Surgery and Translational Medicine, University of Florence Medical School, Florence, Italy; 2 Dermatology Unit, IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy; 3 Dermatologic Clinic, Department of Medical Sciences, University of Turin, Turin, Italy; 4 Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy


Primary Cutaneous B-cell Lymphomas comprehend a group of lymphoproliferative disorders characterized by being monoclonal proliferations of B-cell primarily involving the skin. Despite being recognized as autonomous and distinct clinico-pathologic entities since the late 80s, their classification is still an ongoing matter of debate. At the moment, WHO classification recognizes three disorders: primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma and primary cutaneous diffuse large B-cell lymphoma, leg type. Primary cutaneous diffuse large B-cell lymphoma, other has been used to define rare cases which show histologically an infiltrate with diffuse pattern composed by large B-cell, but not fitting with criteria for follicle center lymphoma nor for primary cutaneous diffuse large B-cell lymphoma, leg type. Aim of this review is to briefly describe all recognized and provisional entities included in the primary cutaneous B-cell lymphomas and to discuss recent acquisitions that may influence their future classifications.

KEY WORDS: Lymphoma B-cell marginal zone - Lymphoma large B-cell diffuse - Lymphoma non hodgkin

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Publication History

Article first published online: November 16, 2017
Manuscript accepted: October 5, 2017
Manuscript revised: September 22, 2017
Manuscript received: April 26, 2017

Per citare questo articolo

Grandi V, Alberti Violetti S, La Selva R, Cicchelli S, Delfino C, Fava P et al. Primary cutaneous B-cell lymphoma: narrative review of the literature. G Ital Dermatol Venereol 2017 Nov 16. DOI: 10.23736/S0392-0488.17.05670-X

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