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Giornale Italiano di Dermatologia e Venereologia 2019 August;154(4):457-65

DOI: 10.23736/S0392-0488.19.06294-1

Copyright © 2019 EDIZIONI MINERVA MEDICA

lingua: Inglese

Dermoscopy of Spitz/Reed naevi and management

Chryssoula PAPAGEORGIOU 1, Zoe APALLA 1, 2, Mattheos BOBOS 3, Theodosia GKENTSIDI 1, Athanassios KYRGIDIS 4, Konstantinos LALLAS 1, Sofia-Magdalini MANOLI 1, Andreas MOUTSOUDIS 1, Christina NIKOLAIDOU 5, Ioannis SPYRIDIS 1, Aimilios LALLAS 1

1 First Department of Dermatology, Aristotle University, Thessaloniki, Greece; 2 State Clinic of Dermatology, Hospital for Skin and Venereal Diseases, Thessaloniki, Greece; 3 Microdiagnostics Pathology Laboratory, Thessaloniki, Greece; 4 Department of Clinical Pharmacology, Aristotle University, Thessaloniki, Greece; 5 Department of Histopathology, Hippokration General Hospital, Thessaloniki, Greece



Since their first description by Sophie Spitz, Spitz nevi have been a subject of controversy among clinicians for many decades, and remain a clinical conundrum until today as their etiology, morphology, biological behavior and natural evolution is still not totally clear. This is because their clinical, dermoscopic and histopathologic features sometimes overlap with those of melanoma, rendering the management of spitzoid lesions particularly difficult. In addition, cases of histopatologically equivocal lesions do exist and their classification might sometimes be very challenging. Among several terms that have been used to describe these morphologically “intermediate” lesions, atypical Spitz tumor (AST) is the most widely used. The aim of this review paper was to describe the dermoscopic patterns and structures seen in Spitz/Reed nevi, spitzoid melanoma and AST. Finally, this article provides an evidence-based update on the available options for the management of spitzoid lesions, before and after histopathologic diagnosis.


KEY WORDS: Nevus, epithelioid and spindle cell; Dermoscopy; Melanoma

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