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Giornale Italiano di Dermatologia e Venereologia 2019 August;154(4):405-12

DOI: 10.23736/S0392-0488.18.05874-1

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Action of surfactants on the mammal epidermal skin barrier

Clara BARBA 1 , Alessandra SEMENZATO 2, Gianni BARATTO 3, Luisa CODERCH 1

1 IQAC-CSIC, Barcelona, Spain; 2 Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padua, Italy; 3 UNIFARCO S.p.A, S. Giustina, Belluno, Italy



BACKGROUND: Daily skin washing routines can promote undesirable effects on skin barrier function. The stratum corneum (SC) lipid matrix is crucial for skin barrier function. Skin cleansing products are mostly composed of surfactants: surface-active molecules that interact with skin lipids in several ways. The main aim of this work was to investigate the effect produced by surfactants on skin barrier permeability. Porcine skin is a well-accepted and readily available model of the human skin barrier. The effect of two cleansing formulations (based on different surfactant mixtures) on the barrier properties of mammalian skin were evaluated.
METHODS: Water sorption/desorption (DVS) experiments were used to measure skin permeability. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy and confocal Raman were useful to study SC lipid organization.
RESULTS: The results showed that while anionic surfactants (SLS) had a negative impact on the skin barrier, with a clear increase of alkyl chain disorder; cosurfactants present in the shampoo formulation diminished the detrimental effect of their primary ionic surfactant, inducing less modification on lipid intramolecular chain disorder.
CONCLUSIONS: The obtained results confirmed that the mild cleansing formulations studied had gentle interaction with skin. The capacity to discriminate between detergent systems was clearly established with both DVS and spectroscopy techniques.


KEY WORDS: Skin barrier; Spectrum analysis; Surface-active agents; Lipids; Permeability

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