Home > Riviste > Giornale Italiano di Dermatologia e Venereologia > Fascicoli precedenti > Giornale Italiano di Dermatologia e Venereologia 2018 December;153(6) > Giornale Italiano di Dermatologia e Venereologia 2018 December;153(6):866-71

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi PROMO
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Publication history
Estratti
Permessi
Per citare questo articolo

 

ORIGINAL ARTICLE   

Giornale Italiano di Dermatologia e Venereologia 2018 December;153(6):866-71

DOI: 10.23736/S0392-0488.18.05710-3

Copyright © 2018 EDIZIONI MINERVA MEDICA

lingua: Inglese

Novel combination for the treatment of acne differentiated based on gender: a new step towards personalized treatment

Ersilia TOLINO , Nevena SKROZA, Alessandra MAMBRIN, Nicoletta BERNARDINI, Sara ZUBER, Veronica BALDUZZI, Anna MARCHESIELLO, Ilaria PROIETTI, Concetta POTENZA

“Daniele Innocenzi” Unit of Dermatology, Department of Medical-Surgical Science and Biotechnologies, Sapienza University of Rome, A. Fiorini Hospital, Terracina, Latina, Italy



BACKGROUND: The aim of this study is to evaluate efficacy and tolerability of a complete skin care line consisting of an oral supplement in two distinct formulations for males and females, and a topical cream device in the treatment of mild and moderate acne. Oral supplements contain biotin, probiotic, vitamin E, zinc, nicotinamide; in the formulation for males beta sitosterol and Boswellia serrata were added, the oral supplement for females contains myo-inositol and folic acid. The topical cream device is represented by the association between active plant agents (verbascoside, Ocimum gratissimum) and keratolytic molecules (salicylic acid, gluconolactone, complex alpha-hydroxy acids).
METHODS: An equal number of male and female patients with mild to moderate acne were enrolled in a double-blinded clinical trial. Efficacy and tolerability evaluations were performed at week 4 (T1) and week 12 (T2) by Global acne Grading System (GAGs).
RESULTS: Most of patients had satisfactory therapeutic response, in terms of GAGs reduction. All the four groups presented a statistically significant improvement of the mean GAGs at T2 but those assuming the oral supplement improved more, as expected.
CONCLUSIONS: Our data suggest that this association can be considered a new effective option for mild and moderate acne. This therapeutic line differs from others in the gender matched oral treatment.


KEY WORDS: Acne vulgaris - Administration, topical - Dietary supplements

inizio pagina