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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Rivista di Dermatologia e Malattie Sessualmente Trasmesse


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2018 April;153(2):276-7

DOI: 10.23736/S0392-0488.16.05084-7

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Pustular eruption associated with granulocyte colony-stimulating factor treatment

Maria B. BRUMANA 1, Irene RUSSO 1, Renato ZAMBELLO 2, Mauro ALAIBAC 1

1 Unit of Dermatology, University of Padua, Padua, Italy; 2 Unit of Hematology, University of Padua, Padua, Italy


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We report a case of localized pustular eruption on the face in a patient with Hodgkin lymphoma treated with granulocyte colony-stimulating factor for the development of chemotherapy-induced neutropenia. The administration of granulocyte colony-stimulating factor and the level of neutrophils were closely associated with disease activity, and negative cultures ruled out the hypothesis of an infective etiology. Because of the role of colony-stimulating factor in mobilization of the neutrophils we considered this phenomenon a skin reaction caused by granulocyte colony-stimulating factor-driven neutrophil accumulation.


KEY WORDS: Granulocyte colony-stimulating factor - Skin diseases, vesiculobullous - Hodgkin disease

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Publication History

Issue published online: March 20, 2018
Article first published online: November 15, 2016
Manuscript accepted: April 15, 2015
Manuscript received: March 29, 2015

Per citare questo articolo

Brumana MB, Russo I, Zambello R, Alaibac M. Pustular eruption associated with granulocyte colony-stimulating factor treatment. G Ital Dermatol Venereol 2018;153:276-7. DOI: 10.23736/S0392-0488.16.05084-7

Corresponding author e-mail

mauro.alaibac@unipd.it