CASE REPORT   

Giornale Italiano di Dermatologia e Venereologia 2018 April;153(2):276-7

DOI: 10.23736/S0392-0488.16.05084-7

Copyright © 2015 EDIZIONI MINERVA MEDICA

lingua: Inglese

Pustular eruption associated with granulocyte colony-stimulating factor treatment

Maria B. BRUMANA ¹, Irene RUSSO ¹, Renato ZAMBELLO ², Mauro ALAIBAC ¹ ✉

¹ Unit of Dermatology, University of Padua, Padua, Italy; ² Unit of Hematology, University of Padua, Padua, Italy

We report a case of localized pustular eruption on the face in a patient with Hodgkin lymphoma treated with granulocyte colony-stimulating factor for the development of chemotherapy-induced neutropenia. The administration of granulocyte colony-stimulating factor and the level of neutrophils were closely associated with disease activity, and negative cultures ruled out the hypothesis of an infective etiology. Because of the role of colony-stimulating factor in mobilization of the neutrophils we considered this phenomenon a skin reaction caused by granulocyte colony-stimulating factor-driven neutrophil accumulation.

KEY WORDS: Granulocyte colony-stimulating factor - Skin diseases, vesiculobullous - Hodgkin disease