REVIEW   Free

Giornale Italiano di Dermatologia e Venereologia 2018 February;153(1):68-76

DOI: 10.23736/S0392-0488.17.05795-9

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

Pathways in melanoma development

Tal H. ERLICH ¹, David E. FISHER ^{1, 2} ✉

¹ Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA; ² Department of Dermatology, Massachusetts General Hospital, Boston, MA, USA

This review aimed to summarize the current advances in melanoma research and their clinical relevance. Until recently, melanoma was considered an incurable disease. However, in recent years tremendous advances have been made in therapeutics. This is due to profound understanding of the molecular pathways involved in melanoma development. Although new targets are always emerging, understanding how to overcome resistance to current treatments is of great interest.

KEY WORDS: Melanoma - Molecular targeted therapy - Immunotherapy