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GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA

Rivista di Dermatologia e Malattie Sessualmente Trasmesse


Official Journal of the Italian Society of Dermatology and Sexually Transmitted Diseases
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Giornale Italiano di Dermatologia e Venereologia 2017 December;152(6):658-62

DOI: 10.23736/S0392-0488.16.05376-1

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Intralesional (incision) biopsy for melanoma diagnosis: the rules and the exception

Elvira MOSCARELLA 1 , Giuseppe ARGENZIANO 2, Claudia MORENO 3, Simonetta PIANA 4, Aimilios LALLAS 1, Mara LOMBARDI 1, Caterina LONGO 1, Gerardo FERRARA 5

1 Unit of Dermatology and Skin Cancer, 1st Medical Department, Arcispedale Santa Maria Nuova Institute for Research and Care, Reggio Emilia, Italy; 2 Department of Dermatology, Second University of Naples, Naples, Italy; 3 Department of Dermatology, Clinical Hospital University of Chile, Santiago, Chile; 4 Department of Dermatopathology, Arcispedale Santa Maria Nuova Institute for Research and Care, Reggio Emilia, Italy; 5 Unit of Anatomic Pathology, Gaetano Rummo General Hospital, Benevento, Italy


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Intralesional (incision) biopsy for melanoma diagnosis can be warranted for large lesions or for those lesions whose in-toto excision leads to cosmetic and/or functional impairment. However, this diagnostic approach carries a risk of underdiagnosis, if a clinicopathologic diagnostic approach is not implemented. As a rule, in large pigmented lesions from special body areas (scalp and acral skin), clinicodermoscopic differential diagnosis of melanoma includes non-melanocytic skin lesions, traumatic skin changes, and nevi. The unique indication to incision biopsy for the differential diagnosis between nevus and melanoma is a relatively small nodular proliferation developing within a medium-large congenital nevus.


KEY WORDS: Dermoscopy - Histology - Melanoma - Skin diseases - Biopsy

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Publication History

Issue published online: October 18, 2017
Article first published online: April 20, 2016
Manuscript accepted: April 19, 2016
Manuscript received: April 4, 2016

Per citare questo articolo

Moscarella E, Argenziano G, Moreno C, Piana S, Lallas A, Lombardi M, et al. Intralesional (incision) biopsy for melanoma diagnosis: the rules and the exception. G Ital Dermatol Venereol 2017;152:658-62. DOI: 10.23736/S0392-0488.16.05376-1

Corresponding author e-mail

elvira.moscarella@gmail.com