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Giornale Italiano di Dermatologia e Venereologia 2017 December;152(6):638-41

DOI: 10.23736/S0392-0488.16.05442-0

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Prognostic role of histological regression in cutaneous melanoma

Simone RIBERO 1, 2 , Simona OSELLA-ABATE 3, Emi DIKA 4, Eugenio SPORTOLETTI BADUEL 2, Elena MARRA 1, Franco PICCIOTTO 2, Virginia CALIENDO 2, Maria T. FIERRO 1, Pietro QUAGLINO 1

1 Section of Dermatology, Department of Medical Sciences, University of Turin, Turin, Italy; 2 Section of Dermatologic Surgery, Department of Oncology, University Hospital “Città della Salute e della Scienza di Torino”, Turin, Italy; 3 Section of Surgical Pathology, Department of Medical Sciences, University of Turin, Turin, Italy; 4 Unit of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy


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Histological regression in primary cutaneous melanoma occurs in 10-35% of cases. Although there is a large body of literature on histological regression and prognosis in melanoma patients, not clear data concerning this feature has been reported. In the current review, a comprehensive overview of the main aspects of regression will be provided. The clinical utility of regression as a prognostic factor has been challenged recently. Nowadays evidences reported that this feature is protective on SLN metastases. Despite its association with poor prognostic factors, it maintained a favourable prognostic role in many different survival studies.


KEY WORDS: Melanoma - Survival - Histology

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