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Giornale Italiano di Dermatologia e Venereologia 2017 June;152(3):302-7

DOI: 10.23736/S0392-0488.17.05567-5

Copyright © 2017 EDIZIONI MINERVA MEDICA

lingua: Inglese

“Active” photoprotection: sunscreens with DNA repair enzymes

Matteo MEGNA, Serena LEMBO, Nicola BALATO, Giuseppe MONFRECOLA

Department of Dermatology, Federico II University, Naples, Italy


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Ultraviolet (UV) radiation exerts different harmful effects on human health, being the main etiological agent of certain skin cancers and photoaging. In this context, photoprotection, intended as a set of measures adopted to limit and prevent the effects of UV radiation, plays a critical role in avoiding undesired sunlight outcomes. Traditional sunscreens represent a widely used photoprotective approach, even if they exert a “passive photoprotection” and are not effective once damage to skin cells has been generated after sun exposure. Conversely, “active” photoprotection is represented by topical sunscreens including also antioxidants and liposome-containing DNA repair enzymes, which may constitute a photostrategy filling the current gap in sun protection. In the current review, we focused on “active” photoprotection at a topical level, reporting present knowledge and future prospective regarding DNA repair enzymes such as photolyase, endonuclease and 8-oxoguanine glycosylase which are able to enhance the protective power of traditional sunscreens.


KEY WORDS: Sun protection factor - Skin care - Endonucleases - Deoxyribodipyrimidine photo-lyase - Human oxoguanine glycosylase 1 - DNA damage - DNA repair

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