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Giornale Italiano di Dermatologia e Venereologia 2017 February;152(1):66-70

DOI: 10.23736/S0392-0488.16.04778-7

Copyright © 2014 EDIZIONI MINERVA MEDICA

lingua: Inglese

Long-term survival after multidisciplinary management of a metastatic sarcomatoid porocarcinoma with repeated exeresis, radiotherapy, chemotherapy and cetuximab: case report and review of literature

Agostino PONZETTI 1, Simone RIBERO 2, Virginia CALIENDO 2, Rosella SPADI 1, Giuseppe MACRIPÒ 2, Patrizia LISTA 1

1 Medical Oncology Division, Department of Hematology and Oncology, “Città della Scienza e della Salute”, San Giovanni Battista Hospital, Turin, Italy; 2 Dermatologic Surgery Unit, Department of Hematology and Oncology, “Città della Scienza e della Salute”, San Giovanni Battista Hospital, Turin, Italy


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Eccrine porocarcinoma is a rare and aggressive skin neoplasm; only two cases of sarcomatoid differentiation have been reported. Whereas surgery is effective as first line treatment, optimal management of recurrent or metastatic porocarcinoma is not defined and needs multidisciplinary approach. Here we described the first reported case of metastatic sarcomatoid porocarcinoma. Our patient experienced multiple recurrences, mainly loco-regional, and was treated with a multidisciplinary treatment, involving surgery, radiotherapy, chemotherapy and target therapy, leading to a more than 4 years survival, from the first recurrence. We conclude that multidisciplinary approach in metastatic porocarcinoma must involve surgeon, radiotherapist and medical oncologist. The combination of local and systemic treatments can delay recurrence and prolong survival also in very aggressive cases.


KEY WORDS: Chemoradiotherapy - Eccrine porocarcinoma - Surgery

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