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Giornale Italiano di Dermatologia e Venereologia 2017 February;152(1):8-12

DOI: 10.23736/S0392-0488.16.05192-0

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

Satellitosis and CD117 immunohistochemical expression correlates with poor outcome in thick vulvar melanoma

Rosa A. SALCEDO-HERNÁNDEZ 1, Leonardo S. LINO-SILVA 2, David ISLA-ORTIZ 1, José A. POSADA-TORRES 1, José G. CHANONA-VILCHIS 2, M. Delia PÉREZ-MONTIEL 2, José M. AGUILAR-ROMERO 3, Jorge A. DOMÍNGUEZ-RODRÍGUEZ 3, Ángel HERRERA-GÓMEZ 1

1 Department of Surgical Oncology, National Institute for Cancer Research, Mexico City, Mexico; 2 Department of Anatomic Pathology, National Institute for Cancer Research, Mexico City, Mexico; 3 School of Medicine, National Autonomous University of Mexico, Mexico City, Mexico


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BACKGROUND: Melanoma of the vulva is the second most common vulvar cancer after epidermoid carcinoma. Patients suffering from this disease usually present with a late-stage disease with a poor prognosis. The prognostic factors reported in previous studies are not homogeneous and the clinical/pathogenic role of c-KIT expression is not clear. Breslow staging currently is the most accurate predictor factor.
METHODS: A clinicopathological study with literature review was performed to identify predictors of prognosis and survival in melanoma of the vulva and investigated the expression of c-KIT (by immunohistochemistry) in 10 patients from the National Institute for Cancer Research (Mexico City).
RESULTS: The 10 patients enrolled were all older women with delayed presentation, high-stage disease and limited response to treatment. Five patients (50%) were found to have c-KIT expression; 4 of them recurred (P=0.01), and ultimately 3 died (P=0.038). We identified satellitosis and c-KIT expression as prognostic predictors for death.
CONCLUSIONS: We conclude that c-KIT expression is a valuable predictor of prognosis and survival, especially in thick (>4 mm) melanomas.


KEY WORDS: Melanoma - Vulvar neoplasms - Proto-oncogene proteins c-KIT - Immunohistochemistry

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