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Chirurgia 2017 December;30(6):206-9

DOI: 10.23736/S0394-9508.17.04643-5


lingua: Inglese

Primary central nervous system lymphoma presenting as giant scalp tumor: a case report with review of literature

Ali M. AL-MASHANI 1 , Neeraj SALHOTRA 1, Azmat ALI 1, Maimuna S. AL SAADI 2

1 Department of Neurosurgery, Khoula Hospital, Muscat, Oman; 2 Department of Histopathology, Khoula Hospital, Muscat, Oman


Asymptomatic primary central nervous system lymphoma in an immuno-competent young adult patient with minimal intracranial but massive extra-cranial growth is extremely rare. We report a 27-year-old, asymptomatic female patient with exclusive complaint of a gradually increasing right parietal swelling over the last 8 months. The swelling over scalp measured 15 X 10 cm and the exact diagnosis remained inconclusive by CT, MRI, fine needle aspiration cytology and CSF examination. Craniotomy was performed believing it to be a meningioma. Immuno histo-chemistry of the excised lesion demonstrated neoplastic cells that were positive for CD20, PAX5, CD10, BCL6, MUM1; but negative for TdT1, BCL2, EBV-LMP1. These features were consistent with diffuse large B-cell lymphoma, germinal centertype. Fifteen months after the surgery that was followed by six cycles of chemotherapy, the patient remains asymptomatic without any evidence of systemic dissemination of the lymphoma.

KEY WORDS: Central nervous system - Lymphoma - Lymphoma, B-cell - Drug therapy

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Publication History

Issue published online: October 2, 2017
Manuscript accepted: January 13, 2017
Manuscript received: September 9, 2016

Per citare questo articolo

Al-Mashani AM, Salhotra N, Ali A, Al Saadi MS. Primary central nervous system lymphoma presenting as giant scalp tumor: a case report with review of literature. Chirurgia 2017;30:206-9. DOI: 10.23736/S0394-9508.17.04643-5

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