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Chirurgia 2017 December;30(6):191-5

DOI: 10.23736/S0394-9508.17.04660-5


lingua: Inglese

Protective effects of curcumin on postoperative adhesions in rat models

Talha SARIGOZ 1 , Yusuf SEVIM 2, Hasan DIRIK 3, Fatih MUTLU 4, Omer TOPUZ 1, Tamer ERTAN 1, Inanc S. SARICI 5

1 Department of General Surgery, Kayseri Training and Research Hospital, Kayseri, Turkey; 2 Department of General Surgery, Numune Training and Research Hospital, Ankara, Turkey; 3 Department of Critical Care Medicine, Erciyes University Faculty of Medicine, Kayseri, Turkey; 4 Department of General Surgery, Adnan Menderes University Faculty of Medicine, Aydin, Turkey; 5 Department of General Surgery, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey


BACKGROUND: Curcumin is the main component of curry spices known as turmeric. Turmeric comes from the Zingiberaceae plant family and it is a traditional Chinese herb used for inflammatory conditions. It has gained popularity over the last decades and became the subject of scientific researches because of its anti-inflammatory and anti-oxidant activity.
METHODS: The present study is an animal experimentation and designed as a pilot study. Twenty-four 5- to 6-week-old female Wistar Albino rats weighing 150-250 g were used. They were randomized into 3 groups as sham, control and study groups each consisting of 8 rats. One percent dimethyl sulfoxide was administered intraperitoneally in control group, and in study group, curcumin powder was dissolved in 1% dimethyl sulfoxide and administered intraperitoneally at a dose of 200 mg/kg. Effects of curcumin on adhesion formation, and oxidative stress were evaluated.
RESULTS: Macroscopic adhesion scores in sham and study groups were significant lower compared to control group (P<0.05). Vascular proliferation, fibroblastic activity, and inflammation scores were identified lower in sham group compared to control group (P<0.05). The oxidative status of the groups was investigated and lower TAS values were detected in sham group compared to control group (P<0.05). Additionally, TOS values were significantly low in the study group compared to control group (P<0.05).
CONCLUSIONS: Curcumin seems reducing intra-abdominal adhesion formation significantly with dose-dependent anti-inflammatory, and antioxidant effects.

KEY WORDS: Curcumin - Wound healing - Curcuma - Animal models

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Publication History

Issue published online: October 2, 2017
Manuscript accepted: March 7, 2017
Manuscript received: January 8, 2017

Per citare questo articolo

Sarigoz T, Sevim Y, Dirik H, Mutlu F, Topuz O, Ertan T, et al. Protective effects of curcumin on postoperative adhesions in rat models. Chirurgia 2017;30:191-5. DOI: 10.23736/S0394-9508.17.04660-5

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