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Italian Journal of Maxillofacial Surgery 2011 April;22(1):27-34


lingua: Inglese

Correlation between salivary gland cancer and chronic infections (HIV, HBV, HCV)

Fini G., Kolokathis A. M., Cascino F., Mici E., Buonaccorsi S., Pacchiarotti A.

Department of Maxillo-Facial Surgery, La Sapienza University of Rome, Rome, Italy


AIM: The aim of this study was to find the possible correlations between the tumors of the minor and major salivary glands and chronic viral diseases such as HIV, HCV and HBV.
METHODS: From January 2002 until September 2009 110 patients (age: 21-82 years) were presented at our clinic with tumors of the minor and major salivary glands. Of these patients, 10 were part of a wider range of patients with HIV and/or HCV and/or HBV. Of these 9 were male and 1 female. The study of patients has been carried out collecting anamnestic data and a general objective examination of the lesions with the assessment of the appearance, shape, texture, size, mobility as compared to lower floors of swelling and tenderness. The ultrasound, magnetic resonance imaging (MRI) and cytological examination (FNAC) have completed the diagnostic pathway.
RESULTS: This study shows an interesting correlation between these infections and tumors of the salivary glands especially the benign, such as the adenoma pleomorphic, the Warthin’s tumor and cysts. The predominant lesion appears to be the pleomorphic adenoma with a rate of 40%, followed by the Warthin’s tumor with 20%, adenocarcinoma with 20%, the basal cell adenoma with 10% and epidermoid cysts with 10% .
CONCLUSION: In conclusion, we raise a question: could be this correlation extended to other chronic infections? To give evidence of this we present a final case report with a presumed correlation between malaria infection and adenoma pleomorphic of parotid gland

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