REVIEW  NEWEST EVIDENCE IN BIOMATERIALS FOR AORTIC AND VALVE GRAFTS 

The Journal of Cardiovascular Surgery 2020 October;61(5):577-85

DOI: 10.23736/S0021-9509.20.11615-X

Copyright © 2020 EDIZIONI MINERVA MEDICA

lingua: Inglese

Vascular grafts and valves that animate, made from decellularized biologically-engineered tissue tubes

Zeeshan H. SYEDAIN ¹, Robroy MACIVER ², Robert T. TRANQUILLO ^{1, 3} ✉

¹ Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA; ² Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN, USA; ³ Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN, USA

Biologically-engineered matrix - a tissue that is grown in vitro from donor cells, decellularized, and stored prior to use as off-the-shelf allografts - offers a promising alternative to current cardiovascular biomaterials. This perspective reviews preclinical studies and clinical trials of vascular grafts and valves comprising biologically-engineered matrix, with a focus on those based on donor dermal fibroblast remodeling of fibrin gel with the capacity to heal and grow following recellularization, via animation of the matrix. It concludes with a discussion of related key clinical considerations.

KEY WORDS: Bioengineering; Tissue engineering; Regenerative medicine; Vascular grafting; Heart valve; Venous valves