![]() |
JOURNAL TOOLS |
eTOC |
Per abbonarsi |
Sottometti un articolo |
Segnala alla tua biblioteca |
ARTICLE TOOLS |
Publication history |
Estratti |
Permessi |
Per citare questo articolo |

I TUOI DATI
I TUOI ORDINI
CESTINO ACQUISTI
N. prodotti: 0
Totale ordine: € 0,00
COME ORDINARE
I TUOI ABBONAMENTI
I TUOI ARTICOLI
I TUOI EBOOK
COUPON
ACCESSIBILITÀ
ORIGINAL ARTICLE CARDIAC SECTION
The Journal of Cardiovascular Surgery 2017 December;58(6):904-8
DOI: 10.23736/S0021-9509.16.09010-8
Copyright © 2015 EDIZIONI MINERVA MEDICA
lingua: Inglese
Control of major pulmonary artery bleeding with a gelatin matrix-thrombin solution: a retrospective analysis
Giuseppe CARDILLO 1 ✉, Francesco CARLEO 1, Marco DI MARTINO 1, Bernardo CIAMBERLANO 1, Pasquale IALONGO 2, Giacomo CUSUMANO 3, Maria DENITZA TINTI 4, Alberto RICCI 5, Stefano CAFAROTTI 6
1 Unit of Thoracic Surgery, Carlo Forlanini Hospital, Rome, Italy; 2 Unit of Radiology, Carlo Forlanini Hospital, Rome, Italy; 3 Unit of Thoracic Surgery, Vittorio Emanuele Polyclinic, Catania, Italy; 4 Unit of Cardiology, San Camillo Hospital, Rome, Italy; 5 Unit of Pulmonology, Sant’Andrea Hospital, Sapienza University, Rome, Italy; 6 Unit of Thoracic Surgery, Bellinzona e Valli Regional Hospital, Bellinzona, Switzerland
BACKGROUND: Intraoperative pulmonary artery (PA) bleeding is common during thoracic surgery. We investigated the efficacy of the gelatin matrix-thrombin solution FloSeal (Baxter International, Deerfield, IL, USA) for control of major PA bleeding.
METHODS: Retrospective data were collected on all intraoperative PA injuries during open or minimally invasive lobectomy or pneumonectomy between January 2000 and January 2014. Patients received either 4/0 prolene sutures (Standard) or the gelatin matrix-thrombin solution, plus sutures as needed (Matrix), with at least 6-month follow-up. Endpoints included time to hemostasis, total blood loss, transfusion and complications.
RESULTS: Of 2809 procedures, 39 (1.4%) had intraoperative PA injury, of which 21 received standard care and 18 the gelatin matrix-thrombin solution. Hemostasis was achieved in all Standard group patients after 2 minutes, and after 5 minutes in Matrix patients. Additional sutures were required in 4 (19.0%) Standard group patients. Three (16.7%) Matrix patients had a second solution application, while 17 (77.8%) received precautionary sutures. Mean blood loss on postoperative day 1 was 836.1±186.1 mL and 957.1±163.0 mL in the Matrix and Standard groups, respectively (P=0.003). Four (22.2%) Matrix patients received postoperative transfusions versus eight (38.0%) Standard patients (P=0.02). Two Standard and no Matrix patients underwent surgical revision. There were no complications and no mortalities.
CONCLUSIONS: Our analysis suggests that the gelatin matrix-thrombin solution is safe and effective for the control of major bleeding following intraoperative PA injury, and may improve outcomes. Further prospective studies are required to confirm our findings.
KEY WORDS: Intraoperative complications - Hemorrhage - Pulmonary artery - FloSeal matrix - Thrombin - Hemostatics