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REVIEWS  BARE NITINOL STENTS IN PERIPHERAL ENDOVASCULAR INTERVENTIONS: IS THIS HISTORY? THE FEMOROPOPLITEAL FIELD 

The Journal of Cardiovascular Surgery 2016 August;57(4):578-85

Copyright © 2016 EDIZIONI MINERVA MEDICA

lingua: Inglese

The role for DCBs in the treatment of ISR

Nicolas BAGUE 1, Bahaa NASR 2, Philippe CHAILLOU 1, 3, Alain COSTARGENT 1, 3, Flora GOUAILLER-VULCAIN 3, Yann GOUËFFIC 1, 3, 4

1 Unit of Vascular Surgey, Thorax Institute, CHU Nantes, Nantes, France; 2 CHU de Brest, Unit of Vascular Surgey, Brest, France; 3 INSERM, U957, Nantes, France; 4 University of Nantes, Nantes, France


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INTRODUCTION: Currently, endovascular therapy is the standard of care for peripheral artery disease. The main issue of these techniques is restenosis which is a complex mechanism associating elastic recoil, constrictive remodelling and intimal hyperplasia. More and more evidence show that drug-coating balloon (DCB) is a promising device to prevent and to treat restenosis. Herein we have reviewed the role for DCB’s in the treatment of in-stent restenosis (ISR).
EVIDENCE ACQUISITION: Currently, few studies are available regarding DCB use for femoropopliteal (FP) ISR treatment. In different studies evaluating DCB for treatment of FP ISR the freedom from target lesion revascularization rate at one year are range from 87% to 92.1%. In comparison to other devices used for treatment of FP ISR such as atherectomy, cutting balloon, standard angioplasty, DCB seems to show better results in terms of freedom from TLR and primary patency. Other devices such as drug-eluting stent, brachytherapy, covered stent show also good results for FP ISR.
EVIDENCE SYNTHESIS: Majority of assessed data on FP ISR treated with DCB derived from uncontrolled study or historical comparisons. Only one randomized, controlled study compared DCB versus standard angioplasty. The FAIR trial showed better results in favour of DCB in terms of freedom from TLR at 12 months (90.8%).
CONCLUSIONS: Drug coating balloon could be the first choice of devices for the treatment of FP ISR, because of its efficacy, its ease of use in comparison with more complex and less efficient devices.

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