Home > Riviste > The Journal of Cardiovascular Surgery > Fascicoli precedenti > The Journal of Cardiovascular Surgery 2008 February;49(1) > The Journal of Cardiovascular Surgery 2008 February;49(1):83-6

ULTIMO FASCICOLO
 

JOURNAL TOOLS

eTOC
Per abbonarsi PROMO
Sottometti un articolo
Segnala alla tua biblioteca
 

ARTICLE TOOLS

Estratti
Permessi

 

ORIGINAL ARTICLES  CARDIAC SECTION 

The Journal of Cardiovascular Surgery 2008 February;49(1):83-6

Copyright © 2008 EDIZIONI MINERVA MEDICA

lingua: Inglese

Chronic atrial fibrillation: decreased actin expression in patients with chronic atrial fibrillation

Schäfler A. E., Friedl R., Hekmat K., Hannekum A., Kirmanoglou K.

Department of Cardiac Surgery University of Ulm Ulm, Germany


PDF


Aim. Chronic atrial fibrillation (AF) is characterized by a severe contractile dysfunction and myolysis, which develops progressively. Myolysis and the remodelling of the cellular ultrastructure is associated with the replacement of sarcomeres by glycogen. The aim of our study was to determine if myolysis is characterized by a reduction in actin concentration.
Methods. Right atrial samples from 18 patients undergoing elective cardiac surgery were excised and immediately frozen in liquid nitrogen. Eight patients had chronic AF (>3 months) and 10 patients were in sinus rhythm (SR). Actin concentration was determined by sodium dodecyl sulfate-polycrylamide gel electrophoresis (SDS-PAGE), Western blot and quantified by optical densitometry.
Results. Immunoblot analysis demonstrated actin expression in all hearts. In myocardial samples from patients with chronic AF we found a 2.1 fold reduction in actin expression. (P<0.001)
Conclusion. The decrease in actin concentration via myolysis, might decrease energy consumption and be an additional mechanism for contractile dysfunction in chronic AF.

inizio pagina