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The Journal of Cardiovascular Surgery 2006 October;47(5):603-8

Copyright © 2006 EDIZIONI MINERVA MEDICA

lingua: Inglese

Predictors of long-term survival with pulmonary metastasectomy for osteosarcomas and soft tissue sarcomas

Suzuki M. 1, 2, Iwata T. 1, Ando S. 1, Iida T. 1, Nakajima T. 1, Ishii T. 3, Yonemoto T. 3, Tatezaki S. 3, Fujisawa T. 2, Kimura H. 1

1 Division of Thoracic Diseases Chiba Cancer Center, Chiba, Japan 2 Department of Thoracic Surgery Graduate School of Medicine Chiba University, Chiba, Japan 3 Division of Orthopedics Chiba Cancer Center, Chiba, Japan


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Aim. The control of pulmonary metastases is important for long-term survival of the patients with osteosarcomas and soft tissue sarcomas.
Methods. To evaluate the efficacy of aggressive pulmonary metastasectomy for those patients, we reviewed 105 cases (44 osteosarcomas, and 61 soft tissue sarcomas) treated in our hospital.
Results. The number of metastases was only the significant risk factor for the curability of the metastasectomy (logistic regression analysis, P=0.0274). The 5-year and 10-year survival rate were 43.6% and 32%. The curability was only independent prognostic factor on multivariate analysis (P=0.0008).
Conclusion. Early detection of pulmonary metastasis, multimodal perioperative treatment, and design for minimizing the volume of resected lung tissues will enable complete and repeat resections for the achievement of long-term survival.

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