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The Journal of Cardiovascular Surgery 2005 June;46(3):271-8


lingua: Inglese

The expression of platelet-derived growth factor and connective tissue growth factor in different types of abdominal aortic aneurysms

Kanazawa S. 1, Miyake T. 2, Kakinuma T. 3, Tanemoto K. 4, Tsunoda T. 5, Kikuchi K. 3

1 Division of Cardiovascular Surgery Himeji Central Hospital, Himeji, Hyogo, Japan 2 Division of Clinical Gene Therapy Graduate School of Medicine, Osaka University, Osaka, Japan 3 Department of Dermatology Graduate School of Medicine University of Tokyo, Tokyo, Japan 4 Department of Thoracic and Cardiovascular Surgery Kawasaki Medical School, Okayama, Japan 5 Department of Gastroenterological Surgery Kawasaki Medical School, Okayama, Japan


Aim. An atherosclerotic abdominal aortic aneurysms (AAAA) differ from inflammatory abdominal aortic aneurysms (IAAA), which are characterized by a non specific inflammatory reaction leading to considerable aneurysmal wall thickness from the media to adventitia and retroperitoneal fibrosis in the surrounding tissue. Platelet-derived growth factor (PDGF) and its receptor have been localized to specific cell types within atherosclerotic plaques. Human connective tissue growth factor (CTGF) is a cysteine rich polypeptide that has similar structures to PDGF and has been implicated in connective tissue formation. PDGF and CTGF may play a role in the development of aneurysmal walls in both AAAA and IAAA.
Methods. Using in situ hybridization technique with DIG-labeled RNA probes and immunostaining, we investigated CTGF gene expression, and expression of PDGF and its receptor protein, in human aneurysmal walls.
Results. Expression of CTGF mRNA was found on vascular smooth muscle cells (VSMC) in specimens from AAAA and IAAA. Strong CTGF expression was localized in VSMC around calcification in AAAA. In IAAA, strong expression of CTGF was observed around inflammatory cells. In the aneurysmal walls of AAAA, PDGF A and B chains were strongly stained on small vessels, and the PDGF β receptor was also strongly stained on VSMC around calcification. In the aneurysmal wall of IAAA, weak expressions of PDGF A and B chains were observed in endothelial cells of vessel walls around the inflammatory cells, but the intensity of expression was much weaker than that on the vessel walls in AAAA.
Conclusions. Such differences in fibrogenic cytokine expression may be involved in characteristic aneurysmal formation.

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