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The Journal of Cardiovascular Surgery 2002 December;43(6):799-802

Copyright © 2009 EDIZIONI MINERVA MEDICA

lingua: Inglese

Plasma hepatocyte growth factor levels after open heart surgery for congenital heart disease

Komai H., Naito Y., Fujiwara K.

Department of Thoracic and Cardiovascular Surgery Wakayama Medical College, Wakayama, Japan


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Background. Hepatocyte ­growth fac­tor (­HGF) is a poly­pep­tide ­which ­acts pro­tec­tive­ly ­against endo­the­lial ­cell dys­func­tion. A ­high plas­ma lev­el of ­HGF is ­shown ­when ­the endo­the­li­um is ­injured. We meas­ured plas­ma ­HGF lev­els dur­ing ­and ­after ­open ­heart oper­a­tions ­for con­gen­i­tal ­heart dis­ease, to elu­ci­date ­its involve­ment ­with endo­the­lial ­cell inju­ry.
Methods. Experimental ­design: pros­pec­tive ­study. Setting: per­i­op­er­a­tive set­ting. Patients: 18 chil­dren elec­tive­ly oper­at­ed ­upon ­for con­gen­i­tal ­heart dis­ease ­using ­CPB.
Results. Plasma ­HGF lev­els (ng/ml) ­before car­di­o­pul­mo­nary ­bypass (­CPB) ­were 0.36±0.07 in 10 chil­dren (S-­group) ­who ­were old­er ­and ­with sim­pler dis­eas­es, ­and 0.48±0.12 in 8 chil­dren (C-­group) ­who ­were young­er ­and ­with rel­a­tive­ly com­plex dis­eas­es. ­HGF lev­els sig­nif­i­cant­ly ­increased ­after ­CPB, ­and grad­u­al­ly ­decreased there­af­ter. Plasma ­HGF lev­els 3 ­and 6 ­hours ­after ­CPB ­were sig­nif­i­cant­ly great­er in ­the C-­group ­than in ­the S-­group (1.13±0.12 vs 1.68±0.1 6 3 ­hours ­after, ­and 1.09±0.19 vs 2.35±0,43 6 ­hours ­after; p<0.05 ­for ­both). There ­were sig­nif­i­cant pos­i­tive cor­re­la­tions ­between ­HGF lev­els 6 ­hours ­after ­CPB ­and ­the dura­tion of ­the ­CPB, ­the aor­tic cross­clamp­ing ­time, ­and plas­ma throm­bo­mod­u­lin lev­els ­just ­after ­CPB in ­all ­patients (p<0.05 ­for ­all).
Conclusions. This ­data sug­gests ­that ­increased ­HGF lev­els ­are asso­ciat­ed ­with endo­the­lial ­cell inju­ry ­induced by ­CPB, ­and ­that ­the increas­es ­are ­much great­er in young­er ­patients ­with com­plex anom­a­lies.

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