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The Journal of Cardiovascular Surgery 1998 April;39(2):233-6

Copyright © 2000 EDIZIONI MINERVA MEDICA

lingua: Inglese

Immunohistochemical properties of lipid peroxidation and prognosis in adenocarcinoma of the lung

Iwasaki M., Ogawa J., Inoue H., Kijima H.*, Watanabe K.*

From the 1st Department of Surgery and *Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan


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Glutathione-relat­ed ­enzymes ­are ­thought to influ­ence ­the prog­no­ses of ­patients ­with aden­o­car­cin­o­ma of ­the ­lung. In ­this ­study, ­the local­iza­tion of ­these ­enzymes ­was exam­ined immu­no­his­to­chem­i­cal­ly in ­the pri­mary ­lesions ­and met­a­stat­ic ­lymph ­nodes of 61 ­patients ­with pri­mary aden­o­car­cin­o­ma. Strong immu­no­reac­tiv­ity ­for glu­tath­i­one per­ox­i­dase (­GSH-PO) ­and super­ox­ide dis­mu­tase (­SOD) ­was ­found in tis­sue ­from ­patients ­with ­poor prog­no­ses, ­while tis­sue ­from ­patients ­with favor­able prog­no­ses dem­on­strat­ed ­only immu­no­reac­tiv­ity ­for ­these ­enzymes. Therefore, ­believe ­that glu­tath­i­one-relat­ed ­enzymes ­may ­serve as pre­dic­tors of ­tumor resis­tance in ­patients ­with aden­o­car­cin­o­ma, ­hence meas­ur­ing ­these ­enzymes ­may be use­ful in deter­min­ing ­the ­need ­for adju­vant ther­a­py.

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